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Real-World Use of Tapinarof Cream 1% Once Daily in Patients with Seborrheic Dermatitis: A Case Series.
J Clin Aesthet Dermatol
January 2025
Ms. Pomaville is with Forefront Dermatology in Berwyn, Illinois; the Marquette University College of Health Sciences, PA Studies Program in Milwaukee, Wisconsin; and the University of Dubuque, MSPAS Program, in Dubuque, Iowa.
Seborrheic dermatitis (SD) is an inflammatory skin disease with multifactorial etiology, involving genetic and environmental factors. Many conventional therapies for SD (ie, topical antifungals, topical corticosteroids) are associated with incomplete efficacy, frequent and sometimes rapid disease recurrence, and restrictions on duration of therapy and anatomic sites of application. This may be because they cannot target multiple disease processes and/or are limited by safety considerations.
View Article and Find Full Text PDFPrimary Systemic Amyloidosis Characterized by Multiple Keratinous Cysts: A Case Report.
J Cutan Pathol
December 2024
Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Article Synopsis
- A 67-year-old male presented with skin plaques and bruising on the neck and hands for 2 years, along with nail issues.
- Histopathological tests indicated the presence of keratinous cysts and eosinophilic material, which tested positive for Congo red staining.
- A bone marrow biopsy confirmed multiple myeloma, leading to a diagnosis of primary systemic amyloidosis alongside multiple myeloma.
Identification of Associations with Dermatologic Diseases through a Focused GWAS of the UK Biobank.
JID Innov
January 2025
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Article Synopsis
- The UK Biobank contains genotype data for around 500,000 individuals and over 7,000 traits, but many significant relationships are overlooked due to the vast number of tests conducted.
- This study focuses on 13 skin-related conditions and identifies 447 important genetic variants that are more likely to affect protein functions, along with a higher CADD score, indicating their potential impact.
- Through further analysis, the researchers not only confirmed existing pathways related to skin cancers but also discovered five new protein-coding variants linked to conditions like lipomas and systemic lupus erythematosus.
Pemphigus Vulgaris Mimicking Seborrheic Dermatitis: A Case Report.
Cureus
October 2024
Dermatopathology, Institute for Immunofluorescence, Pompano Beach, USA.
This case discusses a 55-year-old patient who was evaluated at a dermatology outpatient clinic for a chronic, pruritic, and painful hyperkeratotic plaque located on her scalp vertex. Given the size of the plaque and its thick, yellow scales, an initial clinical diagnosis of seborrheic dermatitis was favored. However, after weeks of unsuccessful treatment with ketoconazole shampoo, topical fluocinolone 0.
View Article and Find Full Text PDFSSA-ZP on Scalp Seborrheic Dermatitis: Regulating Sebum Levels and Scalp Barrier.
J Cosmet Dermatol
January 2025
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Background: The occurrence of scalp seborrheic dermatitis (SD) is closely related to the production of sebum and scalp barrier function. Supramolecular salicylic acid has the keratolytic and anti-inflammatory properties, and zinc pyrithione is an antifungal drug delivered as a microparticle to skin epithelia.
Objective: This study aimed to assess the efficacy and safety of 2% supramolecular salicylic acid (SSA) combined with 0.
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