Here we report the design, single crystal conformations, impact of the substituents and structural differences of two structurally important motifs, β-sheets and β-double helices. Though β-sheets are common structural motifs in protein structures, β-double helices are not common in proteins and peptides. We found that both β-sheet mimetics and β-double helices can be constructed from the homooligomers of α,β-unsaturated γ-amino acids. Results suggested that introducing gem-dialkyl substitutions at the γ-carbon of the homooligomer of α,β-unsaturated γ-amino acids resulted in the β-double helix conformation, while the same oligomer with monosubstitution at the γ-carbon displayed a β-sheet structure.

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http://dx.doi.org/10.1039/c9ob01801hDOI Listing

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