AI Article Synopsis
- The cerebellum has a unique modular structure with climbing fiber (CF) projections that vary based on specific marker expression, but the functional implications of these projections remain unclear.
- Using two-photon calcium imaging in mice, researchers examined how CF inputs in cerebellar module Crus II affect behavior during an auditory task, revealing different CF signal patterns in medial and lateral modules.
- The study shows that medial module CF signals are linked to quick motor initiation and reward responses, while lateral module signals are associated with no-go cues and rewards, suggesting that distinct CF inputs contribute to different aspects of goal-directed behavior.
Article Abstract
The cerebellum has a parasagittal modular architecture characterized by precisely organized climbing fiber (CF) projections that are congruent with alternating aldolase C/zebrin II expression. However, the behavioral relevance of CF inputs into individual modules remains poorly understood. Here, we used two-photon calcium imaging in the cerebellar hemisphere Crus II in mice performing an auditory go/no-go task to investigate the functional differences in CF inputs to modules. CF signals in medial modules show anticipatory decreases, early increases, secondary increases, and reward-related increases or decreases, which represent quick motor initiation, go cues, fast motor behavior, and positive reward outcomes. CF signals in lateral modules show early increases and reward-related decreases, which represent no-go and/or go cues and positive reward outcomes. The boundaries of CF functions broadly correspond to those of aldolase C patterning. These results indicate that spatially segregated CF inputs in different modules play distinct roles in the execution of goal-directed behavior.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844646 | PMC |
| http://dx.doi.org/10.7554/eLife.47021 | DOI Listing |
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