Six new prenylated acylphloroglucinols with menthane moieties, hypascyrins A-E (-) and -hyphenrone J (), together with four known analogues, were isolated from roots. Detailed spectroscopic data analyses resulted in the assignment of their structures. The absolute configuration of was deduced by experimental and calculated ECD data, while those of - were assigned by ECD data analyses as well as chemical conversions. Hypascyrins A (), C (), and E () and -hyphenrone J () exhibited antimicrobial activity against MRSA (MIC values of 4.0, 8.0, 2.0, and 4.0 μM, respectively) and (MIC values of 4.0, 4.0, 2.0, and 4.0 μM, respectively).
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Hypascyrins A-E, Prenylated Acylphloroglucinols from .
J Nat Prod
October 2019
Graduate School of Pharmaceutical Sciences , Tokushima University, Tokushima 770-8505 , Japan.
Six new prenylated acylphloroglucinols with menthane moieties, hypascyrins A-E (-) and -hyphenrone J (), together with four known analogues, were isolated from roots. Detailed spectroscopic data analyses resulted in the assignment of their structures. The absolute configuration of was deduced by experimental and calculated ECD data, while those of - were assigned by ECD data analyses as well as chemical conversions.
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