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Oculomotor challenges in macular degeneration impact motion extrapolation.
J Vis
January 2025
Smith Kettlewell Eye Research Institute, San Francisco, CA, USA.
Macular degeneration (MD), which affects the central visual field including the fovea, has a profound impact on acuity and oculomotor control. We used a motion extrapolation task to investigate the contribution of various factors that potentially impact motion estimation, including the transient disappearance of the target into the scotoma, increased position uncertainty associated with eccentric target positions, and increased oculomotor noise due to the use of a non-foveal locus for fixation and for eye movements. Observers performed a perceptual baseball task where they judged whether the target would intersect or miss a rectangular region (the plate).
View Article and Find Full Text PDFInvestigation into the PSD characteristics of internally unstable soils susceptible to suffosion.
Sci Rep
January 2025
College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing, 210098, China.
Internal instability of embankment soils under seepage can occur in two distinct ways: suffusion and suffosion. Suffusion involves the removal of fine particles from the matrix without causing significant disturbance to the soil skeleton, while suffosion is characterized by the movement of fine particles accompanied by skeleton collapse or deformation. In terms of dam safety, suffosion poses a greater threat than suffusion.
View Article and Find Full Text PDFProbabilistically constrained vector summation of motion direction in the mouse superior colliculus.
Curr Biol
January 2025
Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA; Department of Biology, University of Virginia, Charlottesville, VA 22904, USA. Electronic address:
Visual motion is a crucial cue for the brain to track objects and take appropriate actions, enabling effective interactions with the environment. Here, we study how the superior colliculus (SC) integrates motion information using asymmetric plaids composed of drifting gratings of different directions and speeds. With both in vivo electrophysiology and two-photon calcium imaging, we find that mouse SC neurons integrate motion direction by performing vector summation of the component gratings.
View Article and Find Full Text PDFHypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.
Sci Rep
January 2025
Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Hypoxia and lipid metabolism play crucial roles in the progression of colorectal cancer (CRC). However, the specific functions of hypoxia- and lipid metabolism-related genes (HLPG) in CRC and their relationships with patient prognosis remain unclear. Differential expression analysis using the TCGA-COAD and GEO databases identified 117 HLPGs through the intersection of the two gene sets.
View Article and Find Full Text PDFIntersection between individual, household, environmental and system level factors in defining risk and resilience for children in Kenya's ASAL: A qualitative study.
PLoS One
January 2025
Institute for Human Development, Aga Khan University, Nairobi, Kenya.
Introduction: Children growing up in arid and semi-arid regions of Sub-Saharan Africa (SSA) face heightened risks, often resulting in poor developmental outcomes. In Kenya, the arid and semi-arid lands (ASAL) exhibit the lowest health and developmental indicators among children. Despite these risks, some children grow up successfully and overcome the challenges.
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