AI Article Synopsis
- A review was conducted on 11 patients experiencing immune checkpoint inhibitor-induced diarrhea between 2015 and 2019, aged 46-81 years, with a median age of 63.
- Colonoscopy results showed that four patients had normal findings, while seven displayed signs resembling ulcerative colitis, including inflammation and erosions, indicating ICI-induced colitis.
- Treatment varied among patients, with five requiring prednisolone and two needing infliximab due to resistance, highlighting the complexity and need for thorough diagnosis through colonoscopy and biopsy for effective management.
Article Abstract
We reviewed the records of patients with immune checkpoint inhibitor (ICI)-induced diarrhea during 2015 to 2019. ICI included nivolumab and ipilimumab. There were 11 patients with ICI-induced diarrhea aged 46-81 years (median, 63 years). On colonoscopy, four patients appeared normal, whereas loss of vascularity, erythema, granularity, erosions or ulcerations apparently mimicking ulcerative colitis were found in seven patients. Those seven patients had acute inflammation, cryptitis, crypt abscess and apoptosis, suggestive of ICI-induced colitis. Five of the seven patients were treated with prednisolone, two of whom were resistant to prednisolone and required infliximab. In contrast, none of the four patients without ICI-induced colitis required further treatment. Our observations suggest that diversity exists in the clinical, endoscopic and histological severity of patients with ICI-induced diarrhea. Colonoscopy together with biopsy is inevitable for the diagnosis of ICI-induced colitis, which requires intensive treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/den.13555 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!