Orthostatic and Exercise Effects in Children Years After Kawasaki Disease.

Pediatr Cardiol

Department of Pediatrics, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka City, Tokyo, 181-8611, Japan.

Published: January 2020

AI Article Synopsis

  • A study was conducted to examine the long-term hemodynamic effects of Kawasaki disease (KD) in children, comparing exercise responses between kids with and without a history of KD.
  • The research involved 60 children who had KD and 60 matched controls, assessing heart rate and blood pressure during treadmill exercise tests.
  • Results showed that children with a history of KD had a significantly higher heart rate when standing and a more pronounced pulse pressure during exercise, suggesting potential long-term impacts on vascular function that previous studies may have overlooked.

Article Abstract

The long-term orthostatic and/or exercise hemodynamic effects in children years after Kawasaki disease (KD) were studied using clinical data from the treadmill exercise test (TMET). Heart rate (HR) and blood pressures (BPs) recorded in TMET were compared between two age, gender, and body scale-matched groups of patients with and without a history of KD. The KD group included 60 patients (9.8 ± 2.7 years old) 6.6 ± 2.6 years after KD without coronary arterial aneurysm. The non-KD group included 60 children (10.2 ± 2.7 years old) with other diagnoses. The exercise tolerance in TMET was not statistically different between the two groups. The KD group had a faster HR on standing than the non-KD group by 8.6% (101.5 ± 12.2 vs. 93.5 ± 15.9 bpm, respectively; P < 0.01), suggesting weaker and/or retarded orthostatic vasoconstriction. The pulse pressure was largely augmented above the 4th stage beyond 160 mmHg in 10.6 versus 0% (5 vs. 0) of the KD and non-KD groups (P < 0.05), respectively, while HR and BPs were not significantly different through exercise stages between the two groups. The KD group also showed a faster HR recovery five minutes after exercise than the non-KD group, by 5.7% (108.0 ± 11.6 vs. 102.2 ± 14.2 bpm, respectively; P < 0.05). Our results might indicate long-term subclinical impacts on the vascular tonus of children years after the disease that have not been recognized in previous studies.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00246-019-02216-xDOI Listing

Publication Analysis

Top Keywords

effects children
8
children years
8
years kawasaki
8
kawasaki disease
8
group included
8
non-kd group
8
orthostatic exercise
4
exercise effects
4
disease long-term
4
long-term orthostatic
4

Similar Publications

Behavior-change lifestyle interventions are fundamental in children and adolescent obesity management. This scoping review discusses optimal behavior-change lifestyle interventions in the treatment of overweight and obesity in children and adolescents. A literature search on diet, physical activity, and behavioral intervention for obesity treatment in children and adolescents aged 0-19 years was conducted in the Cochrane Library, MEDLINE (OVID), EMBASE, and ClinicalTrials.

View Article and Find Full Text PDF

Handgrip Strength has Declined Among Adults, Particularly Males, from Shanghai Since 2000.

Sports Med Open

December 2024

Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, GPO Box 2471, Adelaide, SA, 5001, Australia.

Background: Handgrip strength (HGS) is an excellent marker of general strength capacity and health among adults. We aimed to calculate temporal trends in HGS for adults from Shanghai between 2000 and 2020.

Methods: Adults aged 20-59 years from Shanghai, China, were included.

View Article and Find Full Text PDF

During emergencies like wartime, parents of children with Autism Spectrum Disorder (ASD) face heightened challenges, potentially leading to Parental Burnout (PB). Wartime conditions can exacerbate children's behavioral difficulties, contributing to PB. Protective factors such as successful Emotional Regulation (ER) and perceived social support may mitigate PB.

View Article and Find Full Text PDF

Purpose: Looking while listening (LWL) tasks track eye movements while children view images (e.g., a dog and a ball) and hear an auditory prompt (e.

View Article and Find Full Text PDF

Purpose: Voriconazole (VRC) is recommended for the prevention and treatment of invasive fungal infections in children undergoing hematopoietic stem cell transplantation (HSCT). It demonstrates nonlinear pharmacokinetics (PK) and exhibits substantial inter- and intraindividual variability. Phenytoin sodium (PHT) and methylprednisolone (MP) are commonly used in the early stages of HSCT to prevent epilepsy and graft-versus-host disease.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!