AI Article Synopsis
- The gut microbiota, particularly species like Escherichia coli, plays a critical role in protecting the host from intestinal infections caused by pathogens like Pseudomonas aeruginosa.
- E. coli can produce beneficial metabolites such as lactic and acetic acids, especially when fermented with high sugar concentrations, which inhibit the growth and virulence of P. aeruginosa.
- The study suggests that the metabolic byproducts of E. coli are significant in determining the host's ability to resist infections and highlights potential vulnerabilities in other areas of the body, such as the lungs and wounds, due to a lack of these protective metabolites.
Article Abstract
Gut microbiota acts as a barrier against intestinal pathogens, but species-specific protection of the host from infection remains relatively unexplored. Although lactobacilli and bifidobacteria produce beneficial lactic and short-chain fatty acids in the mammalian gut, the significance of intestinal Escherichia coli producing these acids is debatable. Taking a Koch's postulates approach in reverse, we define Escherichia coli as health-promoting for naturally colonizing the gut of healthy mice and protecting them against intestinal colonization and concomitant mortality by Pseudomonas aeruginosa. Reintroduction of faecal bacteria and E. coli in antibiotic-treated mice establishes a high titre of E. coli in the host intestine and increases defence against P. aeruginosa colonization and mortality. Strikingly, high sugar concentration favours E. coli fermentation to lactic and acetic acid and inhibits P. aeruginosa growth and virulence in aerobic cultures and in a model of aerobic metabolism in flies, while dietary vegetable fats - not carbohydrates or proteins - favour E. coli fermentation and protect the host in the anaerobic mouse gut. Thus E. coli metabolic output is an important indicator of resistance to infection. Our work may also suggest that the lack of antimicrobial bacterial metabolites in mammalian lungs and wounds allows P. aeruginosa to be a formidable microbe at these sites.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783455 | PMC |
| http://dx.doi.org/10.1038/s41598-019-51058-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dual-Stage Cross-Flow Filtration: Integrated Capture and Purification of Virus-Like Particles.
Biotechnol Bioeng
December 2024
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Virus-like particles (VLPs) are a versatile technology for the targeted delivery of genetic material through packaging and potential surface modifications for directed delivery or immunological issues. Although VLP production is relatively simple as they can be recombinantly produced using microorganisms such as Escherichia coli, their current downstream processing often relies on individually developed purification strategies. Integrating size-selective separation techniques may allow standardized platform processing across VLP purification.
View Article and Find Full Text PDFPantoea dispersa Causing Bacteremia and Endocarditis in an Immunocompromised Adult: A Rare Case.
Cureus
November 2024
Department of Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, USA.
Gram-negative rods, namely, and , are the most common causative agents of bacteremia. The genus , another group of Gram-negative rods, is a relatively uncommon cause of bacteremia. Our literature review revealed only eight other cases of infection in humans.
View Article and Find Full Text PDFDiagnostic and Therapeutic Value of Endoscopic Retrograde Cholangiopancreatography in Acute Cholangitis: A Study From Kashmir Valley, India.
Cureus
November 2024
Radiation Oncology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, IND.
Background Cholangitis, or bile duct infection, can present in two primary forms, namely, acute ascending cholangitis (the milder form) and acute fulminant cholangitis (the more severe variety). In all types of cholangitis, bile duct obstruction occurs, with choledocholithiasis (the presence of gallstones in the bile duct) being the leading cause of this blockage. is the most commonly isolated pathogen in these infections.
View Article and Find Full Text PDFA simple predictive model for puerperal infections: emphasizing risk factors and pathogen analysis.
Front Cell Infect Microbiol
December 2024
Department of Obstetrics and Gynecology, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Background: Puerperal infection (PI) accounting for approximately 11% of maternal deaths globally is an important preventable cause of maternal morbidity and mortality. This study aims to analyze the high-risk factors and pathogenic bacteria of PI, design a nomogram to predict the risk of PI occurrence, and provide clinical guidance for prevention and treatment to improve maternal outcomes.
Methods: A total of 525 pregnant women were included in the study.
Bacteriological load in Holstein Friesian cows with dystocia.
Front Vet Sci
December 2024
Department Clinics, Reproduction, Faculty of Veterinary Medicine, University of Life Sciences (IULS), Iași, Romania.
The research took place on a farm in North-Eastern Romania with Holstein Friesian cows aged between 3 and 9 years. Bacteriological investigations were carried out throughout the year 2023, on a total of 35 cows, including 25 multiparous cows and 10 primiparous cows, 23 cows had eutocic parturitions and 12 cows had dystocic parturitions, during the first 3 weeks postpartum. In the case of dystocic parturition, biological samples yielded isolates including 9.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!