AI Article Synopsis
- The study aimed to explore the relationship between telomere length (TL) in granulosa and cumulus cells and TL in leukocytes among 35 egg donors.
- It found no significant correlations between TL in leukocytes and follicular cells, despite cumulus cells having a longer TL compared to leukocytes.
- The findings suggest that telomere measurements in leukocytes may not accurately reflect telomere lengths in follicular cells, indicating different cellular mechanisms for managing telomere shortening.
Article Abstract
Objective: To investigate whether telomere length (TL) in granulosa cells (GC) or cumulus cells (CC) correlates with TL in leukocytes (L).
Design: Prospective noninterventional study.
Setting: Private assisted reproductive technology center.
Patient(s): Thirty-five egg donors were included in the study.
Interventions(s): None.
Main Outcome Measure(s): Average relative leukocyte telomere length (LTL), cumulus cell telomere length (CCTL), and granulosa cell telomere length (GCTL) measurements from each study subject.
Result(s): Participants had a mean age of 25.43 ± 4.57 years, antimüllerian hormone level of 1.90 ± 0.92 ng/mL, antral follicle count of 23.29 ± 5.11, and the mean number of mature oocytes retrieved was 23.29 ± 9.13. No significant association between these variables and GCTL, CCTL, or LTL was found. In addition, no correlation was observed between TL measurements of L vs. CC, L vs. GC, or CC vs. GC. Interestingly, CCTL was significantly higher than LTL (1.54-fold), although no significant differences were found between GCTL vs. CCTL or GCTL vs. LTL.
Conclusion(s): CC from mature follicles have significantly longer telomeres than L, suggesting that the follicular environment could possess different mechanisms to cope against telomere shortening compared with other somatic tissues. Furthermore, these data do not support the utility of telomere DNA measurement in L as an estimate of TL in follicular cells.
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| http://dx.doi.org/10.1016/j.fertnstert.2019.08.089 | DOI Listing |
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