AI Article Synopsis
- A cost-effective, disposable microcell was developed for measuring creatinine levels using a modified screen-printed electrode that incorporates carbon black and iron (III) ions.
- The device requires only a tiny sample volume of 3 μL and works through a method involving the complexing of iron (III) ions with creatinine, followed by electrochemical analysis.
- The sensor demonstrated a reliable linear response for creatinine concentrations between 0.10 and 6.5 mmol/L, with a detection limit of 0.043 mmol/L, and successfully tested real urine samples for accuracy.
Article Abstract
A low-cost and disposable microcell was constructed with a screen-printed electrode for the non-enzymatic electrochemical determination of creatinine. The working electrode was modified with carbon black and maintained in contact with paper-adsorbed iron (III) ions. A small sample volume of 3 μL was required for the device operation. Then, iron (III) ions were complexed in the presence of creatinine in a chemical step, followed by an electrochemical reduction of non-complexed metallic ions in excess. Cyclic voltammetry and differential-pulse voltammetry experiments were employed for the electrochemical characterizations and analytical performance evaluation of the microcell. The working electrode modification with carbon black provided a significant increase of analytical signal. The sensor presented a linear response for creatinine concentrations ranging from 0.10 to 6.5 mmol L, with a limit of detection of 0.043 mmol L. Experiments for creatinine determination in real samples were successful performed through of standard recovery in urine.
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| http://dx.doi.org/10.1016/j.talanta.2019.120277 | DOI Listing |
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