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| http://dx.doi.org/10.3988/jcn.2019.15.4.575 | DOI Listing |
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Full moon mesencephalon sign: a transient cytotoxic lesion in a hemodialysis patient with newly diagnosed atrial fibrillation and severe stenosis of the right vertebral artery.
Neurol Sci
December 2024
Department of Neurology, Martin Gropius Hospital, Eberswalde, Germany.
Brain cytotoxic edema is a neuroradiological sign secondary to variegate diseases ranging from migraine to fulminant Listeria rhombencephalitis. The tempestive identification of its underlying cause is vital for an effective treatment as any delay may be fatal. However, the lack of distinctive imaging biomarkers and the paucity of reports pose a significant challenge in its diagnosis and frequently lead to a misdiagnosis particularly with the more common acute ischemic stroke.
View Article and Find Full Text PDFExpect the unexpected: fulminant myocardial cytotoxic Injury from Trabectedin.
Cardiooncology
October 2024
Memorial Sloan Kettering Cancer Center | Weill Cornell Medicine, 1275 York Ave, New York, NY, 10065, USA.
Background: Trabectedin (Tbt) is an alkylating agent prescribed for soft tissue sarcomas after treatment failure of first line agents. While cardiomyopathy can occur with Tbt treatment after anthracycline exposure, Tbt-induced fulminant myocardial cytotoxic injury in the setting of other systemic cytotoxicity associated with Tbt has not been reported.
Case Presentation: 51-year-old female with hypertension, hyperlipidemia, metastatic leiomyosarcoma with progression of disease despite several lines of chemotherapy including doxorubicin-based therapy was started on Trabectedin (Tbt) 5 days prior to presentation with symptoms of fever, myalgias, arthralgias, and palpitations.
Identification and characterization of a small molecule BFstatin inhibiting BrpR, the transcriptional regulator for biofilm formation of .
Front Microbiol
September 2024
Department of Agricultural Biotechnology, National Research Laboratory of Molecular Microbiology and Toxicology, Seoul National University, Seoul, Republic of Korea.
Many pathogenic bacteria form biofilms that are resistant to not only host immune defenses but also antibiotics, posing a need for the development of strategies to control biofilms. In this study, to prevent biofilm formation of the fulminating foodborne pathogen , chemical libraries were extensively screened to identify a small molecule inhibiting the activity of BrpR, a transcriptional regulator for biofilm genes. Accordingly, the BrpR inhibitor BFstatin [N1-(2-chloro-5-fluorophenyl)-N3-propylmalonamide], with a half-maximal effective concentration of 8.
View Article and Find Full Text PDFIdentification of key immune-related genes and potential therapeutic targets in immune checkpoint inhibitor-associated myocarditis.
Postgrad Med J
September 2024
Department of Cardiology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, No 9, Chongwen Road, Suzhou City 215000, China.
Background: Immune checkpoint inhibitors (ICIs) are widely used in cancer treatment; however, the emergence of ICI-associated myocarditis (ICI-MC) presents a severe and potentially fatal complication with poorly understood pathophysiological mechanisms. This study aimed to identify crucial immune-related genes in ICI-MC and uncover potential therapeutic targets using bioinformatics.
Methods: Using the GSE180045 dataset, which includes three groups-Group A: ICI patients without immune adverse events, Group B: ICI patients with non-myocarditis immune adverse events, and Group C: ICI patients with myocarditis-we analyzed differentially expressed genes (DEGs) between ICI-MC samples (Group C) and non-myocarditis controls (Groups A and B).
Histopathologic correlates of opioid-associated injury in CHANTER syndrome: first report of a post-mortem examination.
Acta Neuropathol
August 2024
Veterans' Home, 91 Crest Avenue, Chelsea, MA, 02150, USA.
Article Synopsis
- * CHANTER syndrome (cerebellar, hippocampal, and basal nuclei transient edema with restricted diffusion) is identified when all these regions are affected, with the first histopathologic findings linked to this syndrome reported in a patient who died from fentanyl overdose.
- * Post-mortem examinations revealed various brain injuries, including microhemorrhage and neuronal necrosis, suggesting that both hypoxic-ischemic and cytotoxic mechanisms contribute to CHANTER syndrome, but further research is necessary for targeted treatments. *
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