As terror groups proliferate and grow in sophistication, a major international concern is the development of scientific methods that explain and predict insurgent violence. Approaches to estimating a group's future lethality often require data on the group's capabilities and resources, but by the nature of the phenomenon, these data are intentionally concealed by the organizations themselves via encryption, the dark web, back-channel financing, and misinformation. Here, we present a statistical model for estimating a terror group's future lethality using latent-variable modeling techniques to infer a group's intrinsic capabilities and resources for inflicting harm. The analysis introduces 2 explanatory variables that are strong predictors of lethality and raise the overall explained variance when added to existing models. The explanatory variables generate a unique early-warning signal of an individual group's future lethality based on just a few of its first attacks. Relying on the first 10 to 20 attacks or the first 10 to 20% of a group's lifetime behavior, our model explains about 60% of the variance in a group's future lethality as would be explained by a group's complete lifetime data. The model's robustness is evaluated with out-of-sample testing and simulations. The findings' theoretical and pragmatic implications for the science of human conflict are discussed.
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http://dx.doi.org/10.1073/pnas.1901975116 | DOI Listing |
Adv Sci (Weinh)
January 2025
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
To bolster the capacity for managing potential infectious diseases in the future, it is critical to develop specific antiviral drugs that can be rapidly designed and delivered precisely. Herein, a CRISPR/Cas13d system for broad-spectrum targeting of influenza A virus (IAV) from human, avian, and swine sources is designed, incorporating Cas13d mRNA and a tandem CRISPR RNA (crRNA) specific for the highly conserved regions of viral polymerase acidic (PA), nucleoprotein (NP), and matrix (M) gene segments, respectively. Given that the virus targets cells with specific receptors but is not limited to a single organ, a Susceptible Cell Selective Delivery (SCSD) system is developed by modifying a lipid nanoparticle with a peptide mimicking the function of the hemagglutinin of influenza virus to target sialic acid receptors.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Influenza remains a persistent global health challenge, largely due to the virus' continuous antigenic drift and occasional shift, which impede the development of a universal vaccine. To address this, the identification of broadly neutralizing antibodies and their epitopes is crucial. Nanobodies, with their unique characteristics and binding capacity, offer a promising avenue to identify such epitopes.
View Article and Find Full Text PDFJ Magn Reson Imaging
January 2025
High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Background: Pancreatic damage is a common digestive system disease with no specific drugs. Static magnetic field (SMF), the key component of magnetic resonance imaging (MRI), has demonstrated prominent effects in various disease models.
Purpose: To study the effects of 0.
Biomed Eng Lett
January 2025
Power Electronics Research Centre, School of Engineering, University of Galway, Galway, Ireland.
Purpose: Pulsed electrical field (PEF) ablation is an energy-based technique used to treat a range of cancers by irreversible electroporation (IRE). Our objective was to use computational and plant-based models to characterize the electric field distribution and ablation zones induced with a commercial 8-needle array-based applicator intended for treatment of skin cancer when high-frequency IRE (H-FIRE) pulses are applied. Electric field characterisation of this device was not previously assessed.
View Article and Find Full Text PDFBMC Neurol
January 2025
Department of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
Background: Malignant brain tumors are among the most lethal cancers. Recent studies emphasized the crucial involvement of the immune system, especially T cells, in driving tumor progression and influencing patient outcomes. The emerging field of immunometabolism has shown that metabolic pathways play a pivotal role in regulating immune responses within the tumor microenvironment.
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