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The Efficacy of Prophylactic Vancomycin in Decreasing Surgical Site Infections in Adolescent Idiopathic Scoliosis Patients: A Large Multicenter Cohort Study.
Iowa Orthop J
January 2025
Department of Orthopaedic Surgery, Shriners for Children Medical Center, Pasadena, California, USA.
Background: The use of vancomycin powder in spine surgery has been supported in adult populations, however, its efficacy in preventing postoperative surgical site infections in AIS patients is yet to be determined.
Methods: A multi-center review was conducted from June 2010 to February 2019, using ICD and CPT codes to identify AIS patients who underwent primary PSF. The patients were divided into two groups: the vancomycin cohort (receiving local vancomycin powder prior to wound closure) and the non-vancomycin cohort.
Analysis of natural structures and chemical mapping data reveals local stability compensation in RNA.
bioRxiv
December 2024
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, 97333, USA.
RNA molecules adopt complex structures that perform essential biological functions across all forms of life, making them promising candidates for therapeutic applications. However, our ability to design new RNA structures remains limited by an incomplete understanding of their folding principles. While global metrics such as the minimum free energy are widely used, they are at odds with naturally occurring structures and incompatible with established design rules.
View Article and Find Full Text PDFRemembering Nightingale in her turbulent times: Introducing the Theory of Integral Nursing in our turbulent times.
Int Nurs Rev
November 2024
Nightingale Initiative for Global Health (NIGH), Santa Fe, New Mexico, USA.
Aim: To connect selected examples from Florence Nightingale's life with concerns for the distress nurses are experiencing worldwide.
Background: We live in turbulent times of disease, armed conflict, vast climate change, and social injustice-factors exacerbating illness and impacting health-factors Nightingale also addressed throughout her life.
Sources Of Evidence: The Theory of Integral Nursing (TIN) is introduced with related examples of nursing's problems and solutions seen through integral lenses at the individual, group, grassroots, and global levels.
Clinical rationale for dietary lutein supplementation in long COVID and mRNA vaccine injury syndromes.
F1000Res
November 2024
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Article Synopsis
- - Lutein is a powerful antioxidant and anti-inflammatory compound found in certain foods that can improve eye health, support heart and metabolic function, and protect against conditions like neurodegenerative diseases and chronic illnesses.
- - It plays a role in mitigating oxidative and nitrosative stress linked to long COVID and mRNA vaccine-related injuries, potentially reducing inflammation caused by the SARS-CoV-2 spike protein.
- - A diet rich in lutein, particularly when combined with Extra Virgin Olive Oil (EVOO) for better absorption, may be beneficial for recovery in post-COVID situations due to its ability to suppress harmful molecular pathways.
Night-time versus daytime surgical outcomes in chronic subdural hematomas: a post hoc analysis of the FINISH randomized trial.
Acta Neurochir (Wien)
October 2024
Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Bridge Hospital, HUS, Haartmaninkatu 4, Po. Box 340, 00029, Helsinki, Finland.
Objective: The optimal timing of surgical intervention for chronic subdural hematomas (CSDH), specifically night-time versus daytime, remains a subject of debate, with concerns about the potential impact of circadian timing on surgical outcomes. This study evaluated the association between the timing of burr-hole drainage for CSDH and postoperative outcomes, comparing night-time and daytime surgeries.
Methods: In a post-hoc analysis of the FINISH trial, we included adult patients with symptomatic unilateral or bilateral CSDH who underwent burr-hole drainage between January 2020 and August 2022.
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