AI Article Synopsis
- Stroke is a significant health issue, contributing to high rates of illness and death in adults, influenced by factors like demographics, medical history, and genetics.
- Research focused on how clinical variables and genetic risk factors impact the early outcomes of ischemic stroke, particularly during the acute phase (first 48 hours) and subacute phase (up to 10 days).
- A review of 61 studies identified critical factors linked to acute stroke outcomes, including glucose and blood pressure levels, atrial fibrillation presence, prior statin use, stroke severity, treatment type, neurological complications, leukocyte counts, and genetic risks, highlighting the need for further studies in this area.
Article Abstract
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. In this review, we expound what is known about the influence of clinical variables and related genetic risk factors on ischemic stroke outcome, focusing on acute and subacute outcome (within 24 to 48 hours after stroke and until day 10, respectively), as they are the first indicators of stroke damage. We searched the PubMed data base for articles that investigated the interaction between clinical variables or genetic factors and acute or subacute stroke outcome. A total of 61 studies were finally included in this review. Regarding the data collected, the variables consistently associated with acute stroke outcome are: glucose levels, blood pressure, presence of atrial fibrillation, prior statin treatment, stroke severity, type of acute treatment performed, severe neurological complications, leukocyte levels, and genetic risk factors. Further research and international efforts are required in this field, which should include genome-wide association studies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780022 | PMC |
| http://dx.doi.org/10.5853/jos.2019.01522 | DOI Listing |
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