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The Expanding Riboverse. | LitMetric

The Expanding Riboverse.

Cells

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA .

Published: October 2019

AI Article Synopsis

  • New studies show that ribosomes are more varied and adaptable than previously thought, challenging the traditional view of a uniform structure.
  • Researchers have discovered significant differences in ribosomal composition and function, which allow for specialization among different species and even within individual cells.
  • This newfound ribosomal diversity opens up possibilities for targeted treatments for diseases and innovations like "designer ribosomes," paving the way for future advancements in biological sciences.

Article Abstract

Subverting the conventional concept of "the" ribosome, a wealth of information gleaned from recent studies is revealing a much more diverse and dynamic ribosomal reality than has traditionally been thought possible. A diverse array of researchers is collectively illuminating a universe of heterogeneous and adaptable ribosomes harboring differences in composition and regulatory capacity: These differences enable specialization. The expanding universe of ribosomes not only comprises an incredible richness in ribosomal specialization between species, but also within the same tissues and even cells. In this review, we discuss ribosomal heterogeneity and speculate how the emerging understanding of the ribosomal repertoire is impacting the biological sciences today. Targeting pathogen-specific and pathological "diseased" ribosomes promises to provide new treatment options for patients, and potential applications for "designer ribosomes" are within reach. Our deepening understanding of and ability to manipulate the ribosome are establishing both the technological and theoretical foundations for major advances for the 21 century and beyond.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829380PMC
http://dx.doi.org/10.3390/cells8101205DOI Listing

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