AI Article Synopsis
- Thyroid function is typically evaluated through TSH and free thyroid hormone levels, which are usually adequate for diagnosis and treatment monitoring.
- However, certain medical conditions, like TSH-secreting tumors or receptor mutations, can lead to misleading results and necessitate different treatments.
- The article highlights the urgent need for new biomarkers to improve the diagnosis and management of thyroid-related disorders, focusing on comparisons between animal models and human data.
Article Abstract
Thyroid function is conventionally assessed by measurement of thyroid-stimulating hormone (TSH) and free circulating thyroid hormones, which is in most cases sufficient for correct diagnosis and monitoring of treatment efficiency. However, several conditions exist, in which these parameters may be insufficient or even misleading. For instance, both, a TSH-secreting pituitary adenoma and a mutation of thyroid hormone receptor β present with high levels of TSH and circulating hormones, but the optimal treatment is substantially different. Likewise, changes in thyroid hormone receptor α signaling are not captured by routine assessment of thyroid status, as serum parameters are usually inconspicuous. Therefore, new biomarkers are urgently needed to improve the diagnostic management and monitor treatment efficiency for e. g., replacement therapy in hypothyroidism or thyroid hormone resistance. By comparing animal models to human data, the present minireview summarizes the status of this search for new tissue- and pathway-specific biomarkers of thyroid hormone action.
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| http://dx.doi.org/10.1055/a-1012-8484 | DOI Listing |
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