One nucleotide substitution (C>T) in codon 228 of HLA-C*04:06:01 results in the novel allele, HLA-C*04:06:03.
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Article Synopsis
- - Approved vaccines are good for preventing severe COVID-19, but new variants and transmission need a stronger immune response, leading to the creation of modified live-attenuated vaccines (LAVs) that recode the SARS-CoV-2 genome.
- - The new vaccines, called OTS-206 and OTS-228, are designed to be safe and effective, with OTS-228 showing no side effects or transmission in animal studies, and can be given intranasally.
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