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An Epidemiological Study on in Tibetan Yaks from the Qinghai-Tibet Plateau Area in China.
Animals (Basel)
December 2024
College of Animal Science, Tibet Agricultural and Animal Husbandry University, Nyingchi 860000, China.
is an important foodborne pathogen that can cause a range of illnesses in humans; it has also been a key focus for monitoring in the field of public health, including gastroenteritis, sepsis, and arthritis, and can also cause a decline in egg production in poultry and diarrhea and abortion in livestock, leading to death in severe cases, resulting in huge economic losses. This study aimed to investigate the isolation rate, antimicrobial resistance, serotypes, and genetic diversity of isolated from yak feces in various regions on the Qinghai-Tibet Plateau. A total of 1222 samples of yak dung were collected from major cities in the Qinghai-Tibet Plateau area, and the sensitivity of the isolated bacteria to 10 major classes of antibiotics was determined using the K-B paper disk diffusion method for drug susceptibility.
View Article and Find Full Text PDFSalmonella infections are widely known to cause gastroenteritis, especially in areas of poor hygiene and sanitation. Common symptoms include sustained fever, chills, and abdominal pain. Sepsis, disseminated intravascular coagulation (DIC), various neurological manifestations, and multiorgan failure are other uncommon presentations.
View Article and Find Full Text PDFTwo multidrug-resistant clones carrying extended spectrum beta-lactamases revealed in a single hospital department by whole genome sequencing.
Heliyon
December 2024
Central Research Institute of Epidemiology, Novogireevskaya str., 3a, 111123, Moscow, Russia.
bacteria is a component of normal intestinal microflora of humans and animals, but can also be found in hospital settings causing urinary tract infections and sepsis. The problem of treating such infections is complicated by multidrug-resistant isolates producing extended spectrum beta-lactamases (ESBL), and the number of ESBL-carrying strains has significantly increased recently. This study presents a detailed analysis of 12 multidrug-resistant isolates obtained from the wounds of different patients in one surgical department of a multidisciplinary hospital in Moscow, Russia, using the short- and long-read whole genome sequencing.
View Article and Find Full Text PDFConcomitant Therapy of Inactivated CECT7121 with Fluoroquinolones in a Enteritidis Murine Sepsis Model.
Indian J Microbiol
December 2024
Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Paraje Arroyo Seco, Campus Universitario, 7000 Tandil, Buenos Aires, Argentina.
Optimization of existing antimicrobial therapies is a strategy proposed for extending antimicrobial activity and delaying resistance development. This study aimed to assess the effect of inactivated CECT7121 (I-EFCECT7121) in a combined therapy with Enrofloxacin or Ciprofloxacin in a Enteritidis murine sepsis model. Firstly, dose titration studies were performed to set up: (a) Enteritidis (SE) Lethal dose 99 (LD99) and (b) safety of I-EFCECT7121 (c) I-EFCECT7121 dosage scheme.
View Article and Find Full Text PDFSalmonella: Infection mechanism and control strategies.
Microbiol Res
December 2024
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Zhejiang Research Institute of Tianjin University (Shaoxing), Shaoxing 312300, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, China. Electronic address:
Salmonella is a foodborne pathogen that predominantly resides in the intestinal tract of humans and animals. Infections caused by Salmonella can lead to various illnesses, including gastroenteritis, bacteremia, septicemia, and focal infections, with severe cases potentially resulting in host mortality. The mechanisms by which Salmonella invades host cells and disseminates throughout the body are partly understood, but there are still many scientific questions to be solved.
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