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Angiogenic factors alone or in combination with ultrasound Doppler criteria for risk classification among late-onset small fetuses with or without pre-eclampsia.
Ultrasound Obstet Gynecol
January 2025
BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, IDIBAPS, University of Barcelona, Barcelona, Spain.
Objective: To investigate the prognostic value of maternal angiogenic factors in late-onset small fetuses, alone or in combination with the ultrasound and Doppler parameters currently used for the classification of low-risk small-for-gestational-age (SGA) fetuses or high-risk fetal growth restriction (FGR), overall and according to the presence or absence of pre-eclampsia.
Methods: This was a prospective cohort study of women with a singleton pregnancy with a diagnosis of late-onset fetal smallness (defined as birth weight < 10 centile) and a gestational age of ≥ 34 weeks at delivery. Ultrasound assessment of estimated fetal weight (EFW) and Doppler assessment of uterine artery pulsatility index (UtA-PI) and cerebroplacental ratio (CPR) were performed every 1-2 weeks.
Inter-Laboratory Validation of Nodal/Paranodal Antibody Testing.
J Peripher Nerv Syst
March 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Background And Aims: Reliable detection of antibodies against nodal targets is vital for the diagnosis of autoimmune nodopathies. The performance characteristics of recently developed in-house assays are unknown. We compared testing at four centres.
View Article and Find Full Text PDFRelationships of maternal hemodynamics in the third trimester with fetal umbilical artery doppler indices, estimated fetal weight and birth weight in women with and without congenital heart disease.
Int J Gynaecol Obstet
January 2025
Imperial College London, Chelsea And Westminster Hospital, London, UK.
Objective: To compare differences in maternal hemodynamics, measured non-invasively by impedance cardiography and mean arterial blood pressure (MAP)-at rest and with high-intensity exercise-between pregnant women with corrected congenital heart disease (CHD) and low-risk (LR) pregnant controls, and to correlate these findings with umbilical artery Doppler in the third trimester, estimated fetal weight (EFW) and birth weight (BW).
Methods: Prospective longitudinal study with hemodynamic exercise studies and fetal ultrasound between 30 and 34 weeks' gestation. Approval was obtained from London South East Research Ethics Committee.
Evaluation of fetal aortic isthmus diameter and flow in pregnant women with intrahepatic cholestasis of pregnancy; may it be a marker of poor perinatal outcomes?
J Obstet Gynaecol Res
February 2025
University of Health Sciences, Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
Aim: To evaluate the fetal aortic isthmus (AoI) diameter and flow in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP).
Methods: In this prospective case-control study, fetal AoI diameter and Doppler measurements were performed in the ICP group (n: 30) and the control group (n: 42). Clinical characteristics, fetal AoI diameter and Doppler measurements, serum bile acid levels, liver enzyme levels, and obstetric and perinatal outcomes were compared between the groups.
Impact of Successive Sets of High-Intensity Leg Press on Cerebral Hemodynamics Across Menstrual Cycle Phases.
Am J Physiol Regul Integr Comp Physiol
January 2025
Department of Kinesiology, Faculty of Science, McMaster University, Hamilton, ON, Canada.
This study examined how successive sets of high-intensity leg press (LP) resistance exercise impact the cerebral pressure-flow relationship in untrained males and eumenorrheic females not taking oral contraceptives, and assessed how menstrual cycle (MC) phase influences the cerebral pressure-flow relationship and cerebral hemodynamics (middle cerebral artery blood velocity; MCAv; via transcranial Doppler ultrasound) during and after LP exercise in females. Young adults (11M;11F) performed three sets of leg-press exercises at 90% of their 1-repetition maximum. Data from males and females in early follicular phase were pooled together.
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