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Immune checkpoint inhibition for the treatment of renal cell carcinoma. | LitMetric

AI Article Synopsis

  • The treatment landscape for metastatic renal cell carcinoma (mRCC) is shifting from older therapies, like tyrosine kinase inhibitors (TKIs) and mTOR inhibitors, to newer immune checkpoint inhibitors and their combinations with TKIs.
  • This review summarizes clinical trial results, highlighting the effectiveness of immune checkpoint inhibition, particularly for patients classified as intermediate and poor risk according to the International Metastatic RCC Database Consortium (IMDC).
  • Recent findings show that combining TKIs with immune checkpoint inhibitors, such as axitinib with pembrolizumab or avelumab, has improved overall survival and progression-free survival compared to traditional sunitinib treatment, emphasizing the search for predictive biomarkers to refine treatment choices further.

Article Abstract

: The systemic therapy in metastatic renal cell carcinoma (mRCC) is moving from tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors to immune checkpoint inhibitors and its combination with TKIs.: This review provides a general overview using immune checkpoint inhibition for the treatment of RCC. Clinical results from conducted and ongoing clinical trials are summarized and checkpoint inhibition is reviewed in the context to other available systemic therapies such as TKIs for mRCC based on the different International Metastastic RCC Database Consortium (IMCD) risk groups. Furthermore, prospects for the use of predictive biomarkers in the decision-making process of chosen therapy will be given.: Using checkpoint inhibition in mRCC has demonstrated a superior efficacy for patients with IMDC intermediate and poor risk for ipilimumab combined with nivolumab. Furthermore, therapeutic regimes with tyrosine kinase inhibition plus immune checkpoint-inhibition were recently presented and demonstrated superiority in all risk groups for axitinib plus pembrolizumab in overall survival and progression-free survival (PFS) and axitinib plus avelumab in PFS compared to sunitinib monotherapy. Novel biomarkers of response to further optimize therapeutic selection and patient outcomes are ongoing medical objectives.

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http://dx.doi.org/10.1080/14712598.2020.1677601DOI Listing

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