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Assessment of radon level and the associated radiological risk from soil samples of quarry area at Hakim Gara, Ethiopia.
Environ Monit Assess
December 2024
School of Nuclear and Allied Sciences, University of Ghana, Atomic Campus, P.O. Box LG 80 Legon, Accra, Ghana.
Excavation of terrestrial surface of the Earth could enhance the chance of exposure to radon while gases in the underground get access to escape. This study was aimed to assess the level of radon concentration from soil samples of quarrying sites at Hakim Gara in Ethiopia using CR-39 detectors in sealed container technique. The results of the measured radon concentration level were ranging from 164.
View Article and Find Full Text PDFBiodistribution and dosimetry of the PET radioligand [F]CHDI-650 in mice for detection of mutant huntingtin aggregates.
EJNMMI Res
December 2024
μNEURO Research Centre of Excellence, Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.
Background: Huntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mHTT aggregates in the brain, with positron emission tomography (PET), will allow to reliably evaluate the efficacy of therapeutic interventions in HD. This study aimed to assess the radiation burden of [F]CHDI-650, a novel fluorinated mHTT radioligand, in humans based on both in vivo and ex vivo biodistribution in mice and subsequent determination of dosimetry for dosing in humans.
View Article and Find Full Text PDFDiagnostic accuracy of sentinel lymph node biopsy and wire localized clipped node biopsy after neoadjuvant chemotherapy in node-positive breast cancer.
Surg Today
December 2024
Breast Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Purpose: The optimal method for axillary staging in patients with initially node-positive breast cancer after NACT remains unclear.
Methods: We conducted a prospective, single-center trial to investigate the diagnostic performance of sentinel lymph node biopsy (SLNB) combined with wire localized lymph node biopsy (WLNB) of the clip-marked node as an axillary staging technique in patients with node-positive breast cancer after neoadjuvant chemotherapy (NACT).
Results: A total of 233 patients were enrolled, 208 of whom were included in the analysis.
Association Between Serum Thyrotropin and Cancer Recurrence in Differentiated Thyroid Cancer: A Population-Based Retrospective Cohort Study.
Thyroid
December 2024
Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Levothyroxine to suppress thyrotropin (TSH) to <0.5 mIU/L following thyroidectomy in differentiated thyroid cancer (DTC) may reduce recurrence in higher-risk DTC. However, there is limited evidence to support guideline recommendations to maintain TSH in the low-normal range of 0.
View Article and Find Full Text PDFContrast-enhanced ultrasound may be effective for the measurement of the free distal segment length of the internal carotid artery in carotid body tumours.
Clin Radiol
November 2024
Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China.
Aim: This pilot study aimed to determine whether contrast-enhanced ultrasound (CEUS) is effective for measuring the free distal segment length of the internal carotid artery (FDS-ICA) in carotid body tumours (CBTs).
Materials And Methods: Thirty-seven patients with 38 confirmed CBTs were enrolled. Before surgery, all patients underwent grey scale ultrasound (US), colour Doppler US (CDU), and CEUS.
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