Objective: Neonatal sepsis is a global public health concern in general and causes a massive burden in developing countries particularly in sub-Saharan Africa. Though it is mostly preventable, neonatal sepsis remained the leading cause of mortality in developing countries. This study was conducted to determine the current proportion and identify factors associated with neonatal sepsis to suggest directions.
Results: In this study 504 randomly selected neonatal charts were reviewed. The proportion of overall neonatal sepsis was 63.69% (95% CI 59.38, 67.79), where early-onset sepsis was 59.33% (95% CI 54.96, 63.55) and late-onset sepsis was 4.17% (95% CI 2.73, 6.31). Maternal intra-partum fever, season of birth and admission, vaginal mode of delivery and preterm gestational age at birth increased the likelihood of overall and early-onset neonatal sepsis. In conclusion of this study, neonatal sepsis remaining the leading cause of morbidity among younger infants. Intra-partum conditions were major contributors to neonatal sepsis. Thus, providing emphasis on associated factors in particular and universal safe obstetric care in general is recommended.
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http://dx.doi.org/10.1186/s13104-019-4685-2 | DOI Listing |
Introduction: Preterm birth (PTB) is associated with newborn morbidity and mortality. DNA methylation plays an important role in the development of fetus, thus can also serve as an epigenetic biomarker. Limited epigenetic studies were conducted in regard to PTB.
View Article and Find Full Text PDFAm J Infect Control
December 2024
Department of Microbiology, Vietnam National Children's Hospital, Hanoi, Vietnam.
Mymensingh Med J
January 2025
Dr Md Arif Rabbany, Junior Consultant, Department of Neonatology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail:
Sepsis is a leading cause of neonatal morbidity and mortality worldwide, especially in low- and middle- income countries (LMIC). It is estimated to cause almost 1 million deaths that accounts for more than 25.0% of neonatal deaths worldwide.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Neonatal Health Nursing, School of Nursing, College of Medicine and Health Sciences, and Specialized Hospital, University of Gondar, Gondar, Ethiopia.
Phototherapy is the preferred treatment for neonatal hyperbilirubinemia and has largely replaced exchange transfusions due to its effectiveness and safety. The primary aim of this study was to evaluate the time to recovery and its predictors among neonates undergoing phototherapy at the Neonatal Intensive Care Unit of the Northwest Comprehensive Specialized Hospital in Northwest Ethiopia. A multi-center institution-based retrospective follow-up study was conducted among 423 neonates admitted to the neonatal intensive care unit between September 2019 and December 2023, at Comprehensive Specialized Hospitals of Northwest Ethiopia.
View Article and Find Full Text PDFJ Infect Dis
December 2024
Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, a division of the National Health Laboratory Service, Johannesburg, South Africa.
Background: Group B Streptococcus (GBS) is a leading cause of neonatal meningitis and sepsis and an important cause of disease in adults. Capsular polysaccharide and protein-based GBS vaccines are currently under development.
Methods: Through national laboratory-based surveillance, invasive GBS isolates were collected from patients of all ages between 2019 and 2020.
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