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Functionalization of activated methylene C-H bonds with nitroarenes and sulfur for the synthesis of thioamides. | LitMetric

Functionalization of activated methylene C-H bonds with nitroarenes and sulfur for the synthesis of thioamides.

Org Biomol Chem

Faculty of Chemical Engineering, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet, District 10, Ho Chi Minh City, Vietnam.

Published: October 2019

We report a method to obtain arylthioamides by the functionalization of sp C-H bonds in phenylacetic acids and benzyl alcohols. Reactions proceeded without the use of any solvents and were compatible with many functionalities and heterocycles. These conditions allow for a rapid synthesis of thioamides from simple, commercial substrates.

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Source
http://dx.doi.org/10.1039/c9ob01751hDOI Listing

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