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Leptomeningeal Metastases in Renal Cell Carcinoma at Initial Diagnosis: 2 Case Reports and Literature Review. | LitMetric

Leptomeningeal Metastases in Renal Cell Carcinoma at Initial Diagnosis: 2 Case Reports and Literature Review.

Cancer Invest

Department of Medical Oncology, Institut de Cancérologie Lucien Neuwirth , Saint Priest en Jarez , France.

Published: October 2019

AI Article Synopsis

  • Leptomeningeal metastasis (LM) in renal cell carcinoma (RCC) is rare and lacks standardized treatment options.
  • Two reported cases show RCC patients with LM diagnosed initially, both having adjacent skull bone metastasis.
  • The management included surgical resection and radiotherapy for one patient, with systemic treatment postponed based on current RCC guidelines, emphasizing the need for localized curative treatment for LM at diagnosis.

Article Abstract

Leptomeningeal metastasis (LM) in solid tumors are rare, even more in renal cell carcinoma (RCC). To date there is a lack of consensual treatment modalities of leptomeningeal metastasis. Furthermore, with the improvement of outcomes and more effective systemic targeted therapies, the management of leptomeningeal metastasis becomes a real challenge. We here report two cases of RCC with leptomeningeal metastasis at initial diagnosis. Both patients had concurrent adjacent skull bone metastasis. Therapeutic management of both patients consisted in surgical resection, followed by radiotherapy in one case. Systemic treatment was delayed according to current recommendations for the management of metastatic RCC. The aim of this work is to report the therapeutic approach and related outcomes and also provide a review of the currently available literature on leptomeningeal disease in renal cell carcinoma. Indeed, local treatment with curative outcome of meningeal location in RCC should be performed specially in LM at initial diagnosis.

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Source
http://dx.doi.org/10.1080/07357907.2019.1662031DOI Listing

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