AI Article Synopsis
- The study investigates antibiotic-resistant Gram-negative bacteria in water ecosystems of Cali, resulting from pollution from various sources.
- Researchers used culture methods and molecular techniques to analyze bacteria presence in five different locations during dry and wet seasons, employing statistical analysis to determine correlations.
- Findings revealed high levels of resistance, particularly to cefoxitin and cefotaxime, with the most resistance identified in artificial waters; this raises concerns about the spread of antibiotic resistance genes in the Rio Cauca.
Article Abstract
Introduction: Pollution by domestic, industrial, and hospital wastes of the artificial and natural waters of the city of Cali led us to investigate the presence of Gram-negative bacteria resistant to antibiotics in these aquatic ecosystems.
Material And Methods: We used culture-dependent methods and molecular techniques to investigate the prevalence and dynamics of -lactamase producing Gram-negative bacteria in five areas located in channels and rivers that cross the city of Cali in January (dry season) and May (wet season). The association between the variables was determined by the chi-square test, using the statistical package SPSS vs 23.0.
Results: The main species being and spp. with associated resistance to both cefoxitin and cefotaxime were observed in 73.3% isolates during the dry season. Most of the isolates belonged to antibiotype 3 (with resistance to 6 antibiotics), 51.2% in the dry season and 48.9% in the wet season, and they were found especially in the artificial waters of "Intersector Canal (CVC) Sur".
Conclusion: These results indicate that -lactamase-producing Gram-negative bacteria are widespread in the environment in the aquatic ecosystem of Cali city. The artificial and natural waters that cross the city are finally discharged into the Rio Cauca; this river can then be considered as a medium for the spread of bacterial antibiotic resistance genes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754923 | PMC |
| http://dx.doi.org/10.1155/2019/1375060 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Canine urothelial cell model to study intracellular bacterial community development by uropathogenic Escherichia coli.
PLoS One
January 2025
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America.
Urinary tract infections (UTIs) are among the most common bacterial infections of both dogs and humans, with most caused by uropathogenic Escherichia coli (UPEC). Recurrent UPEC infections are a major concern in the treatment and management of UTIs in both species. In humans, the ability of UPECs to form intracellular bacterial communities (IBCs) within urothelial cells has been implicated in recurrent UTIs.
View Article and Find Full Text PDFBiophysical and biochemical evidence for the role of acetate kinases (AckAs) in an acetogenic pathway in pathogenic spirochetes.
PLoS One
January 2025
Department of Microbiology, UT Southwestern Medical Center, Dallas, TX, United States of America.
Unraveling the metabolism of Treponema pallidum is a key component to understanding the pathogenesis of the human disease that it causes, syphilis. For decades, it was assumed that glucose was the sole carbon/energy source for this parasitic spirochete. But the lack of citric-acid-cycle enzymes suggested that alternative sources could be utilized, especially in microaerophilic host environments where glycolysis should not be robust.
View Article and Find Full Text PDFMultiplicity of type 6 secretion system toxins limits the evolution of resistance.
Proc Natl Acad Sci U S A
January 2025
Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.
The bacterial type 6 secretion system (T6SS) is a toxin-injecting nanoweapon that mediates competition in plant- and animal-associated microbial communities. Bacteria can evolve de novo resistance against T6SS attacks, but resistance is far from universal in natural communities, suggesting key features of T6SS weaponry may act to limit its evolution. Here, we combine ecoevolutionary modeling and experimental evolution to examine how toxin type and multiplicity in attackers shape resistance evolution in susceptible competitors.
View Article and Find Full Text PDFA signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
Proc Natl Acad Sci U S A
January 2025
Key Laboratory of Molecular Nanostructure and Nanotechnology, Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Emerging evidence indicates that intratumor bacteria exist as an active and specific tumor component in many tumor types beyond digestive and respiratory tumors. However, the biological impact and responsible molecules of such local bacteria-tumor direct interaction on cancer therapeutic response remain poorly understood. Trastuzumab is among the most commonly used drugs targeting the receptor tyrosine-protein kinase erbB-2 (ErbB2) in breast cancer, but its resistance is inevitable, severely limiting its clinical effectiveness.
View Article and Find Full Text PDFsp. nov., isolated from human epidermis.
Int J Syst Evol Microbiol
January 2025
Department of Bio Health Science, Changwon National University, Changwon, Gyeongnam 51140, Republic of Korea.
Five pink-pigmented bacterial strains, isolated from human skin and classified within the genus , were examined. Among them, four were identified as , while strain OT10 was deemed to be a potential novel species. Strain OT10 exhibited characteristics, such as Gram-stain-negative, oxidase positive, motile, strictly aerobic and rod shaped.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!