Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene have a moderately increased risk of VTE, but the effect of the variant in cancer is unknown. We aimed to investigate the effect of the variant and active cancer on the risk of VTE. Cases with incident VTE (n=640) and a randomly selected age-weighted sub-cohort (n=3,734) were derived from a population-based cohort (the Tromsø study). Cox-regression was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for VTE according to categories of cancer and In those without cancer, homozygosity at the variant was associated with a 70% (HR 1.7, 95% CI: 1.2-2.3) increased risk of VTE compared to non-carriers. Cancer patients homozygous for the variant had a two-fold (HR 2.0, 95% CI: 1.1-3.6) higher risk of VTE than cancer patients without the variant. Moreover, the six-months cumulative incidence of VTE among cancer patients was 6.4% (95% CI: 3.5-11.6) in homozygous carriers of and 3.1% (95% CI: 2.3-4.7) in those without risk alleles. A synergistic effect was observed between and active cancer on the risk of VTE (synergy index: 1.81, 95% CI: 1.02-3.21, attributable proportion: 0.43, 95% CI: 0.11-0.74). In conclusion, homozygosity at the variant and active cancer yielded a synergistic effect on the risk of VTE.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327659 | PMC |
| http://dx.doi.org/10.3324/haematol.2019.224279 | DOI Listing |
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