AI Article Synopsis
- The study investigates the interactions of multimeric complexes formed by alpha-lactalbumin and lactoferrin with oleic acid, focusing on their potential pro-apoptotic effects in tumor cells.
- Using small-angle neutron scattering (SANS), the research reveals that alpha-lactalbumin forms complexes with polydisperse oleic acid micelles, while lactoferrin forms a uniform nanoscale particle system.
- Additionally, both complexes appear to influence chromatin structure in isolated nuclei, suggesting their role in exhibiting specific anti-tumor activities.
Article Abstract
This work focuses on the study of multimeric alpha-lactalbumin oleic acid and lactoferrin oleic acid complexes. The purpose of the research is to study possible mechanisms involved in their pro-apoptotic activities, as seen in some tumor cell cultures. Complexes featuring oleic acid (OA) with human alpha-lactalbumin (hAl) or with bovine alpha-lactalbumin (bAl), and human lactoferrin (hLf) were investigated using small-angle neutron scattering (SANS). It was shown that while alpha-lactalbumin protein complexes were formed on the surface of polydisperse OA micelles, the lactoferrin complexes comprised a monodisperse system of nanoscale particles. Both hAl and hLf complexes appeared to interact with the chromatin of isolated nuclei affecting chromatin structural organization. The possible roles of these processes in the specific anti-tumor activity of these complexes are discussed.
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| http://dx.doi.org/10.1016/j.bbrc.2019.09.116 | DOI Listing |
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