The adequacy of various physically corrected electrocardiographic lead systems for lower primates was compared with the aid of physical models of the cardiac electrical field. Electrolytic tanks fashioned from plaster casts of the thorax of young adult male and female macaques and baboons were used. A dipole source situated at different points in the heart region simulated the electrical activity of the heart. Statistical evaluation and reciprocal comparison of the resultant parameters showed that the proposed modification of the McFee-Parungao lead system for macaques and baboons was most satisfactory, followed by the human variant of the same lead system and then by the variant for dogs. The greatest variability was displayed by parameters determined from measurements made with Frank's lead system, which was ranked last in the evaluation.
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Viruses
December 2024
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA.
Lymphocryptoviruses (LCVs) are ubiquitous gamma-herpesviruses that establish life-long infections in both humans and non-human primates (NHPs). In immunocompromised hosts, LCV infections are commonly associated with B cell disorders and malignancies such as lymphoma. In this study, we evaluated simian LCV-encoded small microRNAs (miRNAs) present in lymphoblastoid cell lines (LCLs) derived from a Mauritian cynomolgus macaque () with cyLCV-associated post-transplant lymphoproliferative disease (PTLD) as well as the viral miRNAs expressed in a baboon () LCL that harbors CeHV12.
View Article and Find Full Text PDFSci Adv
December 2024
Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
The ventral pallidum (VP) is critical for motivated behaviors. While contemporary work has begun to elucidate the functional diversity of VP neurons, the molecular heterogeneity underlying this functional diversity remains incompletely understood. We used single-nucleus RNA sequencing and in situ hybridization to define the transcriptional taxonomy of VP cell types in mice, macaques, and baboons.
View Article and Find Full Text PDFBehav Res Methods
December 2024
Ecology and Evolutionary Biology Program, Texas A&M University, College Station, TX, USA.
Accurate eye tracking is crucial for gaze-dependent research, but calibrating eye trackers in subjects who cannot follow instructions, such as human infants and nonhuman primates, presents a challenge. Traditional calibration methods rely on verbal instructions, which are ineffective for these populations. To address this, researchers often use attention-grabbing stimuli in known locations; however, existing software for video-based calibration is often proprietary and inflexible.
View Article and Find Full Text PDFGeroscience
November 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan-Meier survival curves were computed in 12 translational aging models: baboon, bonnet macaque, chimpanzee, common marmoset, coppery titi monkey, cotton-top tamarin, cynomolgus macaque, Japanese macaque, pigtail macaque, rhesus macaque, squirrel monkey, and vervet/African green. After employing strict inclusion criteria, primary results are based on 12,269 NHPs that survived to adulthood and died of natural/health-related causes.
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November 2024
Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Primates, the most colorful mammalian radiation, have previously served as an interesting model to test the functions and evolutionary drivers of variation in eye color. We assess the contribution of photo-regulatory and communicative functions to the external eye appearance of nine macaque species representing all the branches of their radiation. Macaques' well described social structure and wide geographical distribution make them interesting to explore.
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