The DSM-5 introduced an alternative model of personality disorders that is predicated on the presence of personality dysfunction (Criterion A) and pathological personality traits (Criterion B). Recently, a member of the DSM-5 Personality and Personality Disorder Work Group-Morey-published a measure of Criterion A. Our study (Sleep, Lynam, Widiger, Crowe, & Miller, 2019, this issue) examined the performance of Morey's (2017) Levels of Personality Functioning Scale-Self-Report (LFPS-SR) by testing its factor structure, relations with Axis I and II symptoms, and its incremental validity in predicting traditional personality disorders in comparison to Criterion B traits. In his response, Morey raised a number of issues regarding our examination of the LPFS-SR in relation to its factor structure, discriminant validity, and incremental validity. Moreover, he suggested our approach (i.e., pitting Criterion A vs. B) is emblematic of problems in the field that contributed to the relegating of the AMPD to Section III (on emerging measures and models). In our response, we answer his criticisms. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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J Comp Eff Res
January 2025
Boston Scientific Corporation; 100 Boston Scientific Way, Marlborough, MA, USA.
This study assessed the economic impact of reducing one postoperative visit following inflatable penile prosthesis (IPP) implantation. Scenario analyses were used to model the effects of eliminating one 30-min IPP postoperative visit from the expected 2.5 visits accounted for by the American Medical Association resource-based relative value scale data.
View Article and Find Full Text PDFDisabil Rehabil
January 2025
Graduate Program in Psychology, Federal University of Sergipe, São Cristóvão, Brazil.
Purpose: This systematic review examined studies that addressed physiotherapy intervention approaches to the Quality of Life (QoL) of people with Cerebral Palsy (CP).
Materials And Methods: We conducted a comprehensive search strategy in five databases (PEDro, PubMed, Web of Science, Scopus, and Google Scholar) until 12 February 2024. We assessed the included studies' methodological quality and statistical description using the PEDro scale.
Toxicol Rep
June 2025
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.
The surge in plastic production has spurred a global crisis as plastic pollution intensifies, with microplastics and nanoplastics emerging as notable environmental threats. Due to their miniature size, these particles are ubiquitous across ecosystems and pose severe hazards as they are ingested and bioaccumulate within organisms. Although global plastic production has reached an alarming 400.
View Article and Find Full Text PDFOsteoarthr Cartil Open
March 2025
Department for Health Sciences, Medicine and Research, University of Continuing Education Krems, Krems, Austria.
Objective: Lower limb malalignment can complicate symptoms and accelerate knee osteoarthritis (OA), necessitating consideration in study population selection. In this study, we develop and validate a deep learning model that classifies leg alignment as "normal" or "malaligned" from knee antero-posterior (AP)/postero-anterior (PA) radiographs alone, using an adjustable hip-knee-ankle (HKA) angle threshold.
Material And Methods: We utilized 8878 digital radiographs, including 6181 AP/PA full-leg x-rays (LLRs) and 2697 AP/PA knee x-rays (2292 with positioning frame, 405 without).
Mol Ther Nucleic Acids
March 2025
Comprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Fanconi anemia (FA) is a congenital multisystem disorder characterized by early-onset bone marrow failure (BMF) and cancer susceptibility. While gene addition and repair therapies are being considered as treatment options, depleted hematopoietic stem cell (HSC) pools, poor HSC mobilization, compromised survival during transduction, and increased sensitivity to conventional conditioning strategies limit eligibility for FA patients to receive gene therapies. As an alternative approach, we explored protein replacement by mRNA delivery via lipid nanoparticles (LNPs).
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