Lyme borreliosis is an infective disease that is usually transmitted to humans via biting by bacteria-infected tick. The disease is multisystemic and the affected organs are the skin (Erythema migrans), nervous system, eyes, heart and joints. is the bacterium that causes borreliosis and the hosts are rodents of the genus . In the Balkan region, is the most representative vector. A bite from an infected insect is the most common mode of transmitting ; however, transplacental transmission has also been documented. Pathogenesis of the disease consists of both direct and indirect mechanisms of immunological reactions which result in the production of IgM antibodies to in the first 3-6 weeks, and production of IgG class after 6 weeks. Many skin diseases and skin symptoms mimicking Lyme borreliosis, such as dermatomycosis, erysipelas, and undefined hyperpigmentation must be elaborated and considered for borreliosis, as skin symptoms of borreliosis can imitate many of them.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761476PMC
http://dx.doi.org/10.4081/dr.2019.8021DOI Listing

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