AI Article Synopsis
- Polymorphic variants of a specific gene can elevate the risk for atherosclerosis-related coronary artery disease (CAD) and influence serum lipid levels.
- The study focused on haplotype-tagging single nucleotide polymorphisms in a Caucasian population to assess their link to CAD, its symptoms, and risk factors.
- Results showed no association between the genetic variants and CAD risk, but the common rs3808607 variant was linked to altered total cholesterol and LDL levels; additionally, the C allele and CC genotype of the rs11786580 variant were more common in myocardial infarction patients, with a notable difference based on sex.
Article Abstract
Polymorphic variants of the gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. We studied haplotype-tagging single nucleotide polymorphisms of in the Caucasian population and if they are associated with CAD, its symptoms, and any of its risk factors. We did not find the genetic variants of to be associated with an increased risk of CAD. However, we did find that the common rs3808607 variant is associated with modified concentrations of serum total cholesterol and LDL. We also found that the C allele and the CC genotype of the rs11786580 are more frequent in patients with myocardial infarction. This association was especially strong after the group differentiation by sex.
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| http://dx.doi.org/10.2217/bmm-2018-0462 | DOI Listing |
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