The incidence of neurological disorders such as multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD) is increasing throughout the world, but their pathogenesis remains unclear and successful treatment remains elusive. Bidirectional communications between the central nervous system and gut microbiota may play some role in the pathogenesis of the above disorders. Up to a thousand bacterial species reside in human intestine; they colonize the gut shortly after birth and remain for life. Numerous studies point to the role of microbiota composition in the development, course and treatment of MS, AD and PD.
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http://dx.doi.org/10.1007/s00005-019-00561-6 | DOI Listing |
Unlabelled: The intestinal diarrheal pathogen colonizes the host terminal ileum, a microaerophilic, glucose-poor, nitrate-rich environment. In this environment, respires nitrate and increases transport and utilization of alternative carbon sources via the cAMP receptor protein (CRP), a transcription factor that is active during glucose scarcity. Here we show that nitrate respiration in aerated cultures is under control of CRP and, therefore, glucose availability.
View Article and Find Full Text PDFAlzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system. The interplay between the intestinal microbiota and metabolites is believed to influence brain function and the pathogenesis of neurodegenerative conditions through the microbe-gut-brain axis. Sika deer antler protein possesses neuroprotective properties; however, the precise mechanism by which it improves AD remains unclear.
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January 2025
Southwest State Key Laboratory of Traditional Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China.
This study evaluates the therapeutic impact of Fructus aurantii (FA) stir-baked with tartary buckwheat bran (TBB) on functional dyspepsia (FD), employing a reserpine at the dose of 5 mg/kg to rats. FA, a traditional Chinese herbal medicine, is processed with TBB to enhance its gastrointestinal motility benefits. The study's objectives were to assess the impact of this preparation on intestinal flora, SCFA levels, and metabolomic profiles in FD.
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January 2025
Affiliated Women's Hospital of Jiangnan University, Jiangnan University Wuxi China.
Fatty acids (FAs) and gut bacteria likely play vital roles in intrahepatic cholestasis of pregnancy (ICP). However, the causal connection between FAs, gut microbiota, and ICP has not yet been confirmed. To investigate the associations of FAs, gut bacteria, and ICP, a Mendelian randomization (MR) analysis with two samples was performed to identify the potential causal relationships between FAs and ICP.
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January 2025
Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), College of Life Sciences/Institute of Agro-Bioengineering Guizhou University Guiyang China.
Camellia seed oil (CSO), a potential prebiotic agent, can significantly increase the relative abundance of () in mice gut microbiota following oral administration, this study aims to investigate the enhancing effect in vitro. The results showed that after 24-h co-cultivation with 0.5% (v/v) CSO, the growth of increased from 11.
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