This research focused on examining the sonification properties that can lead people who are blind to distinguish and to identify different sounds. This research included 10 participants, all of whom were examined individually. They listened to a sonified scenario, which was generated by an agent-based NetLogo computer model of a gas particle in a container. The participants identified the different sounds as opposed to examining their ability to identify the value of the sounds or to understand the scientific phenomena as a result of hearing the model scenario. This research found that, in regard to complexity levels, the participants were able to identify stimuli that included up to four sounds. The analyses reveal that in the second trial the participants displayed heightened ability. The long-term practical benefits of this research may well influence program developers in education and rehabilitation for people who are blind. A learning environment based on sonified feedback can address a central need among people who are blind, providing equal access to learning environments equivalent to those available to sighted users and allowing independent interaction with exploratory materials and control of the learning process.
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http://dx.doi.org/10.1080/10400435.2019.1666930 | DOI Listing |
BAY 2413555 is a novel selective and reversible positive allosteric modulator of the type 2 muscarinic acetylcholine (M2) receptor, aimed at enhancing parasympathetic signaling and restoring cardiac autonomic balance for the treatment of heart failure (HF). This study tested the safety, tolerability and pharmacokinetics of this novel therapeutic option. REMOTE-HF was a multicenter, double-blind, randomized, placebo-controlled, phase Ib dose-titration study with two active arms.
View Article and Find Full Text PDFBackground: In TALAPRO-2, the poly(ADP-ribose) polymerase inhibitor talazoparib plus the androgen receptor-signaling inhibitor enzalutamide improved radiographic progression-free survival (rPFS) versus placebo plus enzalutamide (hazard ratio [HR] = 0.63; 95% CI, 0.51-0.
View Article and Find Full Text PDFPsychoradiology
November 2024
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China.
Background: The lack of clearly defined neuromodulation targets has contributed to the inconsistent results of real-time fMRI-based neurofeedback (rt-fMRI-NF) for the treatment of chronic pain. Functional neurosurgery (funcSurg) approaches have shown more consistent effects in reducing pain in patients with severe chronic pain.
Objective: This study aims to redefine rt-fMRI-NF targets for chronic pain management informed by funcSurg studies.
Front Med (Lausanne)
December 2024
Department of Ophthalmology, Zhangye People's Hospital Affiliated to Hexi University, Zhangye, China.
Objective: Blood component therapy has shown promising potential as an emerging treatment for dry eye disease; however, it remains unclear which specific blood component is the most effective. This study aims to compare the efficacy of different blood components in the treatment of dry eye disease through a network meta-analysis, with the goal of providing the latest and most reliable evidence for clinical practice.
Methods: We conducted a systematic search of the PubMed, Web of Science, Cochrane, Embase, and Scopus databases, with the search concluding on June 1, 2024.
BMC Infect Dis
December 2024
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province, PR China.
Background: This study aimed to evaluate the diagnostic performance of ESAT6-CFP10 (EC) skin test in healthy population and determine the factors influencing the booster effect.
Methods: We conducted a randomized, double-blind, parallel controlled trial in healthy population. The experiment was divided into two stages.
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