A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells.

Cheng Zhang Ruilin Guan Xinxing Liao Cheng Ouyang Thomas W Rees Jiangping Liu Yu Chen Liangnian Ji Hui Chao

Chem Commun (Camb)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. and College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, P. R. China.

Published: October 2019

A mitochondria-targeting hetero-binuclear Ir(iii)-Ru(ii) complex was developed as a photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) bifunctional agent to achieve a synergistic effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells.

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http://dx.doi.org/10.1039/c9cc05998a	DOI Listing

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