Inner boundary conditions describe the interaction of groundwater wells with the surrounding aquifer during pumping and are associated with well-skin damage that limits water production and water derived from wellbore storage. Pumping test evaluations of wells during immediate and early time flow require assignment of inner boundary conditions. Originally, these concepts were developed for vertical well screens, and later transferred to wellbores intersecting highly conductive structures, such as preferential flow zones in fractured and karstic systems. Conceptual models for pumping test analysis in complex bedrock geology are often simplified. Classic analytical solutions generally lump or ignore conditions that limit or enhance well productivity along the well screen at the onset of pumping. Numerical solutions can represent well drawdowns in complex geological settings, such as karst systems, more precisely than many analytical solutions by accounting for additional physical processes and avoiding assumptions and simplifications. Suitable numerical tools for flow simulations in karst are discrete pipe-continuum models that account for various physical processes such as the transient hydraulics of wellbores intersecting highly conductive structures during pumping.
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http://dx.doi.org/10.1111/gwat.12947 | DOI Listing |
Hortic Res
January 2025
Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China, 100193.
Appropriate root system architecture (RSA) can improve alfalfa yield, yet its genetic basis remains largely unexplored. This study evaluated six RSA traits in 171 alfalfa genotypes grown under controlled greenhouse conditions. We also analyzed five yield-related traits in normal and drought stress environments and found a significant correlation (0.
View Article and Find Full Text PDFTissue Cell
December 2024
Department of Anatomy, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India. Electronic address:
Thyroid gland which is responsible for the maintenance of metabolism and growth is derived from thyroglossal duct, an outpocketing of foregut. The microscopic study of thyroid gland during development in first, second and third trimesters has utmost significance to understand the several developmental thyroid disorders metabolically and structurally. This study is descriptive observational study carried in tissue sections taken from thyroid gland of still birth and spontaneously aborted human fetuses of first, second and third trimester.
View Article and Find Full Text PDFSheng Li Xue Bao
December 2024
Virtual Simulation and Artificial Intelligence Committee, Chinese Association for Physiological Sciences.
As artificial intelligence technology rapidly advances, its deployment within the medical sector presents substantial ethical challenges. Consequently, it becomes crucial to create a standardized, transparent, and secure framework for processing medical data. This includes setting the ethical boundaries for medical artificial intelligence and safeguarding both patient rights and data integrity.
View Article and Find Full Text PDFSci Rep
January 2025
School of Mechatronics Engineering, Henan University of Science and Technology, Luoyang, 471003, China.
Since the rings of the angular contact ball bearings (ACBBs) are typical highly sensitive quenching thin-walled structure, the microstructure and properties variation of the rings during the heat treatment process are often difficult to be controlled precisely, and then the service life of the bearings is reduced. Therefore, in this study, the combination of the numerical simulation and experimental was carried out during the quenching and tempering process of ACBBs (7008C), the phase transformation of the inner and outer ring during the heat treatment process were explored, and the law of the microstructure evolution and the mechanical properties variation were revealed. Firstly, based on the multi-field coupling theory of temperature, microstructure and stress-strain field, the numerical simulation model of the heat treatment process of the bearing rings was established.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Res
January 2025
Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Neue Stiftingtalstraße 6/4 EAST, 8010 Graz, Austria; BioTechMed, Graz, Austria. Electronic address:
The uptake of Ca by mitochondria is an important and tightly controlled process in various tissues. Even small changes in the key proteins involved in this process can lead to significant cellular dysfunction and, ultimately, cell death. In this study, we used stimulated emission depletion (STED) microscopy and developed an unbiased approach to monitor the sub-mitochondrial distribution and dynamics of the mitochondrial calcium uniporter (MCU) and mitochondrial calcium uptake 1 (MICU1) under resting and stimulated conditions.
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