In the current agricultural scenario, availability of suitable land for cultivation is less and profitable allocation of the land for cultivating crops seems to be a cumbersome task. Crop planning optimization is a major research field in agriculture, in which land optimization is a significant challenge, which falls under the category of combinatorial optimization problems. The main objective of the present research is to maximize the net income from agriculture through optimal land allocation. Bio-inspired algorithms are quite popular in solving combinatorial optimization problems. Social Spider Algorithm (SSA), a new bio-inspired algorithm, is used to solve land optimization problem in this research based on the simulation of cooperative behaviour of social spiders. The agricultural area chosen for case study is the Coimbatore region, located in Tamilnadu state, India and the relevant data for the crops are collected from Tamilnadu Agricultural University Coimbatore, India. The optimal planting area, crop productivity for various land holdings and the water requirements are computed by SSA and the results have shown better directions for agricultural planning to improve the profit with constrained land area and water limitations.
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http://dx.doi.org/10.7717/peerj.7559 | DOI Listing |
The endogenous dynorphin/kappa opioid receptor (KOR) system in the brain mediates the dysphoric effects of stress, and KOR antagonists may have therapeutic potential for the treatment of drug addiction, depression, and psychosis. One class of KOR antagonists, the long-acting norBNI-like antagonists, have been suggested to act by causing KOR inactivation through a cJun-kinase mechanism rather than by competitive inhibition. In this study, we screened for other opioid ligands that might produce norBNI-like KOR inactivation and found that nalfurafine (a G-biased KOR agonist) and nalmefene (a KOR partial agonist) also produce long-lasting KOR inactivation.
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January 2025
Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.
Chronic kidney disease (CKD) prevalence varies widely across different regions of India. We aimed to identify the status of CKD in India, by systematically reviewing the published community-based studies between the period of January 2011 to December 2023. PubMed, Scopus, and EMBASE were searched for peer-reviewed evidence.
View Article and Find Full Text PDFNew Phytol
January 2025
Research Group on Plant Biology under Mediterranean Conditions, Universitat de les Illes Balears (UIB) - Institut d'Investigacions Agroambientals i d'Economia de l'Aigua (INAGEA), Cra. de Valldemossa, km 7.5, Palma, Illes Balears, 07122, Spain.
Int J Equity Health
January 2025
Discipline of Podiatry, School of Health Sciences, Western Sydney University, Dharawal Country, Campbelltown, NSW, Australia.
Increasing use of co-design concepts and buzzwords create risk of generating 'co-design branded' healthcare research and healthcare system design involving insincere, contrived, coercive engagement with First Nations Peoples. There are concerns that inauthenticity in co-design will further perpetuate and ingrain harms inbuilt to colonial systems.Co-design is a tool that inherently must truly reposition power to First Nations Peoples, engendering both respect and ownership.
View Article and Find Full Text PDFBMC Musculoskelet Disord
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School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Background: Physiotherapy has emerged as an important health strategy to deliver lifestyle, exercise and physical activity for people with knee osteoarthritis. However, little is known about the extent to which physiotherapists adhere to clinical practice guidelines. This study aimed to explore the perspectives and care patterns of physiotherapists in Sydney, Australia on their delivery of knee osteoarthritis care and how this aligns with the 2019 Osteoarthritis Research Society International (OARSI) guidelines.
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