We present the design of a Cr:forsterite based single-frequency master-oscillator power-amplifier laser system delivering much higher output energy compared to previous literature reports. The system has four amplifying stages with two-pass configuration each, thus enabling the generation of 24 mJ output energy in the spectral region around 1262 nm. It is demonstrated that the presented Cr:forsterite amplifier preserves high spectral and pulse quality, allowing a straightforward energy scaling. This laser system is a promising tool for tunable nonlinear down-conversion to the mid-infrared spectral range and will be a key building block in a system for high-resolution muonic hydrogen spectroscopy in the 6.8 μm range.
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http://dx.doi.org/10.1063/1.5115105 | DOI Listing |
J Cancer
January 2025
Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China.
Developing new drug delivery systems is crucial for enhancing the efficacy of oncolytic virus (OV) therapies in cancer treatment. In this study, mesenchymal stem cell (MSC)-derived vesicles and oncolytic viruses are exploited to construct a novel formulation. It has been hypothesized that vesicle-coated OVs could amplify cytotoxic effects through superior internalization by tumor cells.
View Article and Find Full Text PDFLaser Photon Rev
October 2024
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Irreproducibility in molecular optical sectioning microscopy has hindered the transformation of acquired digital images from qualitative descriptions to quantitative data. Although numerous tools, metrics, and phantoms have been developed, accurate quantitative comparisons of data from different microscopy systems with diverse acquisition conditions remains a challenge. Here, we develop a simple tool based on an absolute measurement of bulk fluorophore solutions with related Poisson photon statistics, to overcome this obstacle.
View Article and Find Full Text PDFBiomicrofluidics
January 2025
State Key Laboratory of Power Grid Environmental Protection, Wuhan, Hubei 430074, China.
In the field of microfluidics, high-pressure microfluidics technology, which utilizes high driving pressure for microfluidic analysis, is an evolving technology. This technology combines microfluidics and pressurization, where the flow of fluid is controlled by means of high-pressure-driven devices greater than 10 MPa. This paper first reviews the existing high-pressure microfluidics systems and describes their components and applications.
View Article and Find Full Text PDFSmall Methods
January 2025
Fujian Provincial Key Laboratory of Functional Marine Sensing Materials, College of Material and Chemical Engineering, Minjiang University, Fuzhou, 350108, P. R. China.
The cost-effective and scalable synthesis and patterning of soft nanomaterial composites with improved electrical conductivity and mechanical stretchability remains challenging in wearable devices. This work reports a scalable, low-cost fabrication approach to directly create and pattern crumpled porous graphene/NiS nanocomposites with high mechanical stretchability and electrical conductivity through laser irradiation combined with electrodeposition and a pre-strain strategy. With modulated mechanical stretchability and electrical conductivity, the crumpled graphene/NiS nanocomposite can be readily patterned into target geometries for application in a standalone stretchable sensing platform.
View Article and Find Full Text PDFJ Cosmet Dermatol
January 2025
Department of Aesthetic Plastic Surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Background: Surgical scars with textural changes can be disfiguring and uncomfortable for patients. Various laser therapies have shown promise in softening and flattening these scars. Therefore, the authors conducted a systematic review and meta-analysis on the efficacy of fractional CO laser in treating surgical scars.
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