AI Article Synopsis
- Extracellular vesicles are tiny structures that help cells communicate and are being studied for their potential roles in disease protection and as biomarkers or vaccine agents.* -
- This study focuses on how alcohol exposure affects the creation and composition of extracellular vesicles from HeLa cervical cancer cells through controlled experiments with different alcohol concentrations.* -
- Findings show that alcohol significantly reduces the viability of HeLa cells and changes the packaging of certain proteins in extracellular vesicles, highlighting their role in disease initiation and progression.*
Article Abstract
Extracellular vesicles are nanosized vesicles that are under intense investigation for their role in intercellular communication. Extracellular vesicles have begun to be examined for their role in disease protection and their role as disease biomarkers and/or vaccine agents. The goal of this study was to investigate the effects of alcohol exposure on the biogenesis and composition of extracellular vesicles derived from the cervical cancer line, HeLa. The HeLa cells were cultured in exosome-free media and were either mock-treated (control) or treated with 50 mM or 100 mM of alcohol for 24 h and 48 h. Our results demonstrated that alcohol significantly impacts HeLa cell viability and exosome biogenesis/composition. Importantly, our studies demonstrate the critical role of alcohol on HeLa cells, as well as HeLa-derived extracellular vesicle biogenesis and composition. Specifically, these results indicate that alcohol alters extracellular vesicles' packaging of heat shock proteins and apoptotic proteins. Extracellular vesicles serve as communicators for HeLa cells, as well as biomarkers for the initiation and progression of disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966524 | PMC |
| http://dx.doi.org/10.3390/biomedicines7040078 | DOI Listing |
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