Unactivated alkyl chlorides are abundant building blocks in organic synthesis, but they have been rarely engaged in cross-electrophile coupling. Herein, we report a Ni/Ti-cocatalyzed reductive allylic defluorinative cross-coupling between trifluoromethyl alkenes and unactivated alkyl chlorides and bromides, enabling the efficient preparation of diverse functional-group-rich -difluoroalkenes. Notably, synthesis of the -difluoroalkene analogues of azaperone, haloperidol, and benperidol was also accomplished using our method as a key step.
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