AI Article Synopsis
- The study examined the vaginal microbiota of 149 women with Chlamydia trachomatis infection before and after antibiotic treatment over 9 months.
- At diagnosis, the microbiota was mostly dominated by either Lactobacillus iners or various bacteria linked to bacterial vaginosis, with Lactobacillus iners becoming more common after treatment.
- The findings highlight the potential risks of antibiotic treatment on vaginal microbiota, which may contribute to reinfection, emphasizing the need for strategies to maintain healthy vaginal bacteria.
Article Abstract
We characterized the composition and structure of the vaginal microbiota in a cohort of 149 women with genital Chlamydia trachomatis infection at baseline who were followed quarterly for 9 months after antibiotic treatment. At time of diagnosis, the vaginal microbiota was dominated by Lactobacillus iners or a diverse array of bacterial vaginosis-associated bacteria including Gardnerella vaginalis. Interestingly, L. iners-dominated communities were most common after azithromycin treatment (1 g monodose), consistent with the observed relative resistance of L. iners to azithromycin. Lactobacillus iners-dominated communities have been associated with increased risk of C. trachomatis infection, suggesting that the impact of antibiotic treatment on the vaginal microbiota could favor reinfections. These results provide support for the dual need to account for the potential perturbing effect(s) of antibiotic treatment on the vaginal microbiota, and to develop strategies to protect and restore optimal vaginal microbiota.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530545 | PMC |
| http://dx.doi.org/10.1093/infdis/jiz499 | DOI Listing |
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