Propofol accounts for 41% of reported substance abuse cases among anesthesia providers. No guidelines outline appropriate propofol disposal in the healthcare setting. The lack of controlled disposal presents concerns for environmental harm, economic waste, and diversion. An evidence-based practice project was conducted in a large, Midwestern teaching institution to address propofol disposal. Data collected regarding propofol waste and from a survey indicated that Certified Registered Nurse Anesthetists (CRNAs) have limited access to sinks in the operating rooms for disposal, have environmental concerns regarding pouring propofol into the sink, and find propofol vials difficult to open. Interventions tailored to address these barriers included implementing a specially designed bottle opener and activated carbon pouch in each operating room to be used for propofol disposal. A χ² analysis showed that changing CRNA practice from sink disposal to carbon pouch disposal significantly decreased the percentage of unemptied propofol vials remaining in unsecured bins from 25.8% before the intervention to 3.4% after the intervention (P < .0001). Decreasing access for diversion is critical for anesthesia practices, and removing barriers to disposal can help reduce access. This evidence-based practice project demonstrated how tailoring interventions to address identified barriers produced an effective practice change for propofol disposal.
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Basic Clin Pharmacol Toxicol
October 2024
Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.
The healthcare sector is a major contributor of greenhouse gas emissions, and reduction and proper sorting of healthcare waste is essential to achieve sustainable healthcare. This study aimed to characterize the quantity and composition of pharmaceutical waste from a major Danish hospital. Pharmaceutical waste was collected from Odense University Hospital, including departments located in both Odense and Svendborg.
View Article and Find Full Text PDFPLoS One
July 2024
College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Background: Surgical Patients and hospitals are now facing financial strain due to direct anesthetic demand as a result of the development of new anesthetic drugs, equipment, and techniques. Up to 15% of a hospital's pharmacy budget is currently allocated to anesthetic drug expenses. Drug wastage during anesthesia practice is a widespread hidden source of healthcare waste that leads to anesthetic drug shortages as well as poor operating room efficiency.
View Article and Find Full Text PDFCurr Opin Urol
September 2024
Department of Anesthesiology, Critical Care, and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Purpose Of Review: The healthcare sector has a substantial environmental footprint, and the delivery of anesthesia contributes significantly. Inhaled anesthetics themselves are potent greenhouse gases, unused intravenous medication exert toxic effects on the environment, and the increasing reliance on single-use devices has led to an ever-growing amount of solid waste produced in operating rooms. This review discusses many of these environmental impacts and suggests practices to mitigate the environmental footprint of anesthetic practice.
View Article and Find Full Text PDFAnaesth Crit Care Pain Med
August 2024
Department of Anesthesia and Intensive Care Medicine, Klinikum Karlsruhe, Karlsruhe, Germany.
J Toxicol Sci
June 2023
Department of Anesthesiology, Hunan Provincial People's Hospital (The first-affiliated hospital of Hunan normal university), China.
Liver ischemia reperfusion (IR) injury induces hepatic stellate cell (HSC) activation and liver fibrosis. Propofol (PRO) possesses a positive protective effect on liver ischemia reperfusion injury. We aimed to investigate PRO function and mechanism in IR-induced liver fibrosis.
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