Ketamine for chronic depression: two cautionary tales.

J Psychiatry Neurosci

From the The Royal’s Institute of Mental Health Research, Mood Disorders Research Unit, Ottawa, Ont. (Talbot, Phillips, Blier); and the Department of Psychiatry, University of Ottawa, Ottawa, Ont. (Talbot, Phillips, Blier).

Published: November 2019

AI Article Synopsis

  • Research indicates that ketamine is effective in treating chronic depression, but the duration of its benefits post-treatment is unclear.
  • Insights into the challenges following ketamine cessation can help clinicians provide better care and reduce risks for patients.
  • This commentary covers unexpected findings from a pilot study on the use of ketamine infusions for patients with resistant depression.

Article Abstract

A growing body of literature has shown the effectiveness of ketamine for treating chronic depression. How long the beneficial effects of repeated ketamine last once infusions are stopped, however, remains largely unknown. Understanding the challenges that ensue after ketamine cessation can help clinicians optimally guide patients who opt for ketamine treatment and minimize the associated risks. In this commentary, we discuss some unexpected data gathered from participants of a pilot study on the effects of adjunctive ketamine infusion for resistant depression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821514PMC
http://dx.doi.org/10.1503/jpn.190073DOI Listing

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