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Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment.
Nat Commun
January 2025
Dept. of Microbiology and Immunology, Center for Microbial Pathogenesis and Host Inflammatory Responses, and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Gammaherpesviruses are DNA tumor viruses that establish lifelong latent infections in lymphocytes. For viruses such as Epstein-Barr virus and murine gammaherpesvirus 68, this is accomplished through a viral gene-expression program that promotes cellular proliferation and differentiation, especially of germinal center B cells. Intrinsic host mechanisms that control virus-driven cellular expansion are incompletely defined.
View Article and Find Full Text PDFSuccessful Treatment of Low-Flow Vascular Malformation in the Lip Using Intralesional Bleomycin: A Case Report.
Cureus
November 2024
Department of Oral and Maxillofacial Surgery, Meghna Institute of Dental Sciences, Nizamabad, IND.
Vascular malformations (VMs) are congenital abnormalities of blood or lymphatic vessels, present at birth and growing proportionally with the individual. They are classified into types such as capillary, venous, lymphatic, and arteriovenous malformation (AVMs). Symptoms include discoloration, swelling, pain, or functional impairment, depending on the type and location.
View Article and Find Full Text PDFAnalysis of associated malformations by computed tomography in adults with polysplenia syndrome: A pilot study.
PLoS One
December 2024
Department of Medical Imaging, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School of Nanjing Medical University, Suzhou, Jiangsu, China.
Objective: To analytically depict the associated malformations of polysplenia syndrome (PS) in adults via computed tomography (CT).
Materials And Methods: The incidence of malformations associated with PS in twelve adult patients was retrospectively analyzed via CT imaging.
Results: The number of splenic nodules ranged from three to twelve; the splenic nodules were located in the left upper quadrant in nine patients and in the right upper quadrant in three patients.
Perspective: Pathological transdifferentiation-a novel therapeutic target for cardiovascular diseases and chronic inflammation.
Front Cardiovasc Med
November 2024
Department of Cardiovascular Sciences, Lemole Center for Integrated Lymphatics and Vascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Pathological transdifferentiation, where differentiated cells aberrantly transform into other cell types that exacerbate disease rather than promote healing, represents a novel and significant concept. This perspective discusses its role and potential targeting in cardiovascular diseases and chronic inflammation. Current therapies mainly focus on mitigating early inflammatory response through proinflammatory cytokines and pathways targeting, including corticosteroids, TNF-α inhibitors, IL-1β monoclonal antibodies and blockers, IL-6 blockers, and nonsteroidal anti-inflammatory drugs (NSAIDs), along with modulating innate immune memory (trained immunity).
View Article and Find Full Text PDFTargeting Tn Antigen Suppresses Aberrant O-Glycosylation-Elicited Metastasis in Breast Cancer.
J Cell Mol Med
December 2024
Department of Gynecology and Obstetrics, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- - The study investigates the Tn antigen, an abnormal sugar molecule often found in breast cancer, and its relationship to cancer spread (metastasis) and patient outcomes.
- - Researchers discovered that Tn antigen is commonly present in breast cancer tissues, especially in metastatic areas, and its expression is linked to more advanced disease and lower survival rates.
- - Targeting the Tn antigen in breast cancer cells showed promise in reducing their ability to invade and spread, suggesting it could be an effective therapeutic target for treating aggressive breast cancer.
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