AI Article Synopsis
- A patient experienced acute liver failure due to metamizole treatment and recovered quickly after a liver transplant.
- A liver biopsy revealed significant liver damage and inflammation, and a lymphocyte transformation test was positive for metamizole 20 months post-transplant.
- Investigations showed that the metabolites of metamizole were not toxic to liver cells, indicating that the liver damage was likely caused by an immune response rather than direct toxicity.
Article Abstract
We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes. A lymphocyte transformation test performed 20 months after transplantation was positive for metamizole. investigations with -methyl-4-aminoantipyrine (MAA) and 4-aminoantipyrine (AA), the two active metabolites of metamizole, did not reveal relevant toxicity in HepG2 and HepaRG cells. The demonstration of activated lymphocytes by the lymphocyte transformation test and the absence of relevant cytotoxicity by MAA and AA in hepatocyte cell lines suggest an immunological mechanism of metamizole-associated hepatotoxicity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749849 | PMC |
| http://dx.doi.org/10.3389/fphar.2019.00996 | DOI Listing |
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