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Mast Cells as a Component of Spermatogonial Stem Cells' Microenvironment.
Int J Mol Sci
December 2024
Laboratory of Immunophysiology and Immunopharmacology, Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia.
The formation of mature spermatozoa originates from spermatogonial stem cells (SSCs) located near the basement membrane of the seminiferous tubules. This developmental process, known as spermatogenesis, is tightly regulated to ensure continuous sperm production. A critical aspect of this regulation is the balance between SSC differentiation and self-renewal, which is directed by various factors guiding SSCs in either of these two directions.
View Article and Find Full Text PDFDevelopment and Validation of a Clinical Score to Predict Epilepsy After Cerebral Venous Thrombosis.
JAMA Neurol
December 2024
Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Article Synopsis
- A significant portion of patients (1 in 10) experience epilepsy after having cerebral venous thrombosis (CVT), but it's challenging to predict who will be affected.* -
- Researchers created the DIAS3 prognostic score using clinical data from over 1,100 patients to assess the likelihood of developing post-CVT epilepsy based on six clinical variables.* -
- The study found a range of predicted risks for post-CVT epilepsy within one and three years, with successful validation of the score confirming its effectiveness in estimating individual risk.*
Article Synopsis
- Asthma and COPD diagnosis in Russia is problematic, leading to public health issues and economic costs due to inadequate control and diagnostics.
- Effective strategies for improvement include educational initiatives, advanced examination methods, mobile health outreach, and digital medical information systems.
- Utilizing modern approaches in diagnosis and management can enhance patient quality of life and minimize risks of complications and exacerbations.
Multimodal therapy and use of adjunctive therapies to BoNT-A in spasticity management: defining terminology to help enhance spasticity treatment.
Front Neurol
August 2024
Department of Physical Medicine and Rehabilitation, The University of Texas Health Science Center McGovern Medical School, Houston, TX, United States.
Spasticity management should be provided within the context of a comprehensive person-centered rehabilitation program. Furthermore, active goal setting for specific spasticity interventions is also important, with a well-established "more is better" approach. It is critical to consider adjunctive therapy and multimodal approaches if patients are not attaining their treatment goals.
View Article and Find Full Text PDF[Assessment of the efficacy and safety of alemtuzumab in patients with highly active relapsing-remitting multiple sclerosis in Russian population].
Zh Nevrol Psikhiatr Im S S Korsakova
October 2023
Pirogov Russian National Research University, Moscow, Russia.
Objective: To evaluate the severity and frequency of infusion reactions (IR) in patients with highly active relapsing-remitting multiple sclerosis (MS) In Russian population receiving alemtuzumab therapy.
Material And Methods: In retrospective study, we analyzed data from 50 patients with highly active relapsing-remitting multiple sclerosis (MS) from six Regional MS Centers in the Russian Federation who received two courses of alemtuzumab between 2018 and 2022.
Results: Among all IRs, the most frequently reported were hives-like rashes, which were registered in 27 people, mostly of mild severity (70.
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