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| http://dx.doi.org/10.14639/0392-100X-2316 | DOI Listing |
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Innovative treatment of age-related hearing loss using MSCs and EVs with Apelin.
Cell Biol Toxicol
January 2025
Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Utilizing single-cell transcriptome sequencing (scRNA-seq) technology, this study explores the viability of employing mesenchymal stem cells (MSCs) as a therapeutic approach for age-related hearing loss (ARHL). The research demonstrates MSCs' ability to differentiate into inner ear cell subpopulations, particularly hair cells, delivering Apelin via extracellular vesicles (EVs) to promote M2 macrophage polarization. In vitro experiments show reduced inflammation and preservation of hair cell health.
View Article and Find Full Text PDFThe effect of cognitive task and gait speed on gait spatiotemporal parameters in athletes with anterior cruciate ligament reconstruction: Cross-sectional study.
Knee
January 2025
Musculoskeletal Research Center, Department of Physical Therapy, School of Rehabilitation Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Restoring pre-injury normal gait following Anterior Cruciate Ligament Reconstruction (ACLR) is a critical challenge. The purpose of this study was to compare spatiotemporal parameters in athletes following ACL reconstruction with healthy athletes when cognitive load and speed were manipulated.
Methods: Twenty male soccer players with an ACLR history and 20 healthy matched individuals completed walking tasks under four conditions: with and without a cognitive load (auditory Stroop task), and at preferred speed as well as high speed (20% higher than the individual's preferred speed).
Cochlear implantation in adults with acquired single-sided deafness improves cortical processing and comprehension of speech presented to the non-implanted ears: a longitudinal EEG study.
Brain Commun
January 2025
Centre for Cognitive Neuroscience, University of Salzburg, 5020 Salzburg, Austria.
Former studies have established that individuals with a cochlear implant (CI) for treating single-sided deafness experience improved speech processing after implantation. However, it is not clear how each ear contributes separately to improve speech perception over time at the behavioural and neural level. In this longitudinal EEG study with four different time points, we measured neural activity in response to various temporally and spectrally degraded spoken words presented monaurally to the CI and non-CI ears (5 left and 5 right ears) in 10 single-sided CI users and 10 age- and sex-matched individuals with normal hearing.
View Article and Find Full Text PDFExtracellular Matrix Alterations Due to Early-Life Adversity: Implications for Auditory Learning in Male Sprague-Dawley Rats.
Mol Neurobiol
January 2025
Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
This study aimed to investigate the impact of early childhood chronic stress on the development of the brain extracellular matrix (ECM) and how alterations in the ECM following early-life adversity (ELA) affect auditory learning and cognitive flexibility. ELA was induced through a combination of maternal separation and neonatal isolation in male Sprague-Dawley rats, and the success of the ELA model was assessed behaviorally and biochemically. A cortex-dependent go/no-go task with two phases was used to determine the impact of ELA on auditory learning and cognitive flexibility.
View Article and Find Full Text PDFThe influence of aging of the hearing system on the variability of the Carhart effect in middle ear diseases.
Otolaryngol Pol
January 2025
Department of Otolaryngology, Jagiellonian University Medical College, Cracow, Poland.
<b>Introduction:</b> In the course of middle ear diseases, a disturbed influence of the system transmitting sound through the middle ear on the function of the inner ear is observed. The audiometric consequence of the disease process taking place in the middle ear is the shift in bone conduction (BC) thresholds, which is called pseudoperceptive hearing loss (the so-called Carhart effect). The natural process of aging of the hearing system (age-related hearing loss) means that the manifestation of the Carhart effect varies in different age groups.
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