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Today, most research evaluation frameworks are designed to assess mature projects with well-defined data and clearly articulated outcomes. Yet, few, if any, are equipped to evaluate the promise of early-stage research, which is inherently characterized by limited evidence, high uncertainty, and evolving objectives. These early-stage projects require nuanced assessments that can adapt to incomplete information, project maturity, and shifting research questions.
View Article and Find Full Text PDFSialic Acid-Modified NIR-II Fluorophore with Enhanced Brightness and Photoconversion Capability for Targeted Lymphoma Phototheranostics.
Anal Chem
January 2025
School of Life Sciences, Key Laboratory of Space Bioscience & Biotechnology, Northwestern Polytechnical University, Xi'an 710072, China.
Lymphoma is a malignant cancer characterized by a rapidly increasing incidence, complex etiology, and lack of obvious early symptoms. Efficient theranostics of lymphoma is of great significance in improving patient outcomes, empowering informed decision-making, and driving medical innovation. Herein, we developed a multifunctional nanoplatform for precise optical imaging and therapy of lymphoma based on a new photosensitizer (1-oxo-1-benzoo[de]anthracene-2,3-dicarbonitrile-triphenylamine (OBADC-TPA)).
View Article and Find Full Text PDFAdvancements in Hyaluronic Acid Effect in Alveolar Ridge Preservation: A Narrative Review.
Diagnostics (Basel)
January 2025
Department of Periodontology, Faculty of Dental Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
: Tooth extraction induces significant alveolar ridge dimensional changes and soft tissue modifications, often leading to challenges in implant placement or conventional prosthetic rehabilitation. Alveolar Ridge Preservation (ARP) strategies aim to mitigate post-extraction resorption of the alveolar ridge, enhancing both the quality and quantity of bone and soft tissue during healing. Hyaluronic acid (HYA) has emerged as a promising biological agent for ARP due to its osteoinductive, antimicrobial, and anti-inflammatory properties.
View Article and Find Full Text PDFLearning from the community: iterative co-production of a programme to support the development of attention, regulation and thinking skills in toddlers at elevated likelihood of autism or ADHD.
Res Involv Engagem
January 2025
Department of Experimental Psychology, University of Oxford, Oxford, UK.
Programmes designed to support children with known, or increased likelihood of, autism or ADHD often focus on reducing behaviours central to a clinical diagnosis. However, supporting children to pursue their own goals and cope with everyday life through fostering executive function (EF) development, without enforcing neuro-normative assumptions, may be more acceptable to neurodivergent people, and more beneficial. The co-production process for this neurodiversity-affirming programme involved: Review of research priorities identified during published public-and-clinician consultations; iterative programme development through two pilot rounds with a general community sample; and consultation with stakeholders (parents with a connection to autism or ADHD, alongside early years specialists, psychologists and therapists) to check acceptability of the proposal, and refine the logic model and materials.
View Article and Find Full Text PDFTracing the electron transfer behavior driven by hydrophyte-derived carbon materials empowered autotrophic denitrification in iron-based constructed wetlands: Efficacy and enhancement mechanism.
Water Res
January 2025
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address:
Iron-based constructed wetlands (ICWs) displayed great potential in deep nitrogen elimination for low-polluted wastewater. However, the unsatisfactory denitrification performance caused by the limited solubility and sluggish activity of iron substrates needs to be improved in an eco-effective manner. To fill this gap, the bioavailability of iron substrates (iron scraps) affected by wetland biomass-derived carbon materials with potential conductivity were explored.
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