We report the characterization of six carbapenem-resistant (CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistant genes from the hospital. An improved understanding of these transposon and targeted control measures will be very valuable to prevent the CRRS dissemination.
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http://dx.doi.org/10.1128/AAC.01367-19 | DOI Listing |
Forensic Sci Int Synerg
June 2025
Department of Forensic Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Sexual assault is a terrible crime that demands a comprehensive and skilled investigation to gather the perpetrator's biological material. To collect all possible physical and biological evidence, forensic investigation is crucial and should be conducted as soon as possible. The primary focus of such investigations is the detection of male-specific materials.
View Article and Find Full Text PDFCureus
December 2024
Emergency Medicine, Zayed Military Hospital, Abu Dhabi, ARE.
Precision medicine, which customizes healthcare based on individual genetic, environmental, and lifestyle factors, has significantly advanced various medical fields. However, its adoption in emergency medicine remains limited despite the potential to enhance patient outcomes through more accurate diagnostics and personalized treatments. This systematic review examined current evidence on the application of precision medicine in emergency care by analyzing studies published between 2010 and 2024.
View Article and Find Full Text PDFRep Pract Oncol Radiother
December 2024
Department of Biosciences Manipal University Jaipur, Dehmi Kalan, Jaipur-Ajmer Expressway, Jaipur, Rajasthan, India.
Multi-omics approaches are revolutionizing cancer research and treatment by integrating single-modality omics methods, such as the transcriptome, genome, epigenome, epi-transcriptome, proteome, metabolome, and developing omics (single-cell omics). These technologies enable a deeper understanding of cancer and provide personalized treatment strategies. However, challenges such as standardization and appropriate methods for funneling complex information into clinical consequences remain.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Introduction: The Precision Medicine Program (PMP) at the University of Florida (UF) focuses on advancing pharmacogenomics (PGx) to improve patient care.
Methods: The UF PMP, in collaboration with the UF Health Pathology Laboratory (UFHPL), utilized Health Level Seven (HL7) standards to integrate PGx data into Epic's Genomic Module to enhance the management and utilization of PGx data in clinical practice.
Results: A key feature of the Genomic Module is the introduction of genomic indicators-innovative tools that flag actionable genetic information directly within the electronic health record (EHR).
Int Cancer Conf J
January 2025
Department of Hematology and Medical Oncology, Kanagawa Cancer Center, 2-3-2, Nakao, Asahi, Yokohama, Kanagawa 2418515 Japan.
A 50-year-old man presented with a bulky mass in the left thigh and was referred to our department. He showed an impaired Eastern Cooperative Oncology Group performance status of 3 due to swelling of the left thigh and pain. Imaging analysis revealed a large mass measuring 16 cm in the left thigh and right forearm, along with the bilateral adrenal gland, right lung, right axillary lymph nodes, liver, and left femur.
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