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Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite. | LitMetric

AI Article Synopsis

  • The study focuses on enhancing dental adhesives with cetylpyridinium chloride (CPC), an antibacterial agent, by incorporating it into a clay mineral called montmorillonite (CPC_Mont) for long-term effectiveness against tooth caries.
  • CPC_Mont adhesives demonstrated significant antibacterial properties, effectively inhibiting the growth of Streptococcus mutans, a primary bacteria involved in tooth decay, while maintaining strong bonding capabilities and not increasing cytotoxicity.
  • The technology allows for a gradual and rechargeable release of CPC, making it a promising solution for improving dental materials and combating the prevalence of dental caries.

Article Abstract

Long-term anti-bacterial effect is a desired ability of any dental material in combating tooth caries as one of the most common and widespread persistent diseases today. Among several cationic quaternary ammonium compounds with antiseptic properties, cetylpyridinium chloride (CPC) is often used in mouthrinses and toothpastes. In this study, we incorporated CPC in a soft phyllosilicate mineral (clay), referred to as montmorillonite (Mont), to enable gradual CPC release with rechargeability. Besides measuring CPC release and recharge, we examined the anti-bacterial effect, cytotoxicity and bonding effectiveness of five experimental adhesive formulations, prepared by adding 1 and 3 wt% CPC_Mont, 3 wt% Mont (without CPC), and 1 and 3 wt% CPC (without Mont) to the commercial adhesive Clearfil S Bond ND Quick ('C-SB'; Kuraray Noritake). Strong inhibition of Streptococcus mutans biofilm formation by CPC_Mont adhesives was confirmed by optical density and SEM. CPC release from CPC_Mont adhesives was higher and lasted longer than from CPC adhesives, while CPC_Mont adhesives could also be recharged with CPC upon immersion in 2 wt% CPC. In conclusion, CPC_Mont technology rendered adhesives anti-bacterial properties with recharge ability, this without reducing its bonding potential, neither increasing its cytotoxicity. STATEMENT OF SIGNIFICANCE: Dental caries is one of the most prevalent chronic diseases in the population worldwide and is the major cause of tooth loss. In this study, we developed cetylpyridinium chloride (CPC) loaded montmorillonite (CPC-Mont) with a long-term antibacterial efficacy to prevent caries. CPC is an antibacterial agent approved by FDA, used as an OTC drug and contained in oral hygiene aids. CPC-Mont was incorporated in a dental adhesive to gradually release CPC. CPC_Mont technology rendered adhesives anti-bacterial properties with rechargeability, this without reducing its bonding potential, neither increasing its cytotoxicity.

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Source
http://dx.doi.org/10.1016/j.actbio.2019.09.045DOI Listing

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