Chronic administration of NaHS and L-Cysteine restores cardiovascular changes induced by high-fat diet in rats.

Eur J Pharmacol

Departamento de Farmacobiología, Cinvestav Unidad Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Del. Tlalpan, C.P, 14330, México D.F, Mexico. Electronic address:

Published: November 2019

AI Article Synopsis

  • Hydrogen sulfide is key in managing the cardiovascular system, insulin levels, and glucose balance; this study explored the impact of chronic treatments with sodium hydrosulfide (NaHS), L-Cysteine (L-Cys), and DL-Propargylglycine (DL-PAG) on rats fed a high-fat diet (HFD).
  • Rats on the HFD showed undesirable increases in body, metabolic, and cardiovascular metrics, which were positively affected by NaHS and L-Cys, reducing body size and blood pressure issues, while DL-PAG improved metabolic conditions.
  • The treatments' effectiveness suggests that NaHS and L-Cys can combat obesity-related cardiovascular problems, while DL-PAG enhances metabolic health in a high-fat consumption

Article Abstract

Hydrogen sulfide plays an important role in the regulation of the cardiovascular system, insulin secretion, and glucose homeostasis. The aim of the present study was to examine the effects of chronic treatment with sodium hydrosulfide (NaHS), L-Cysteine (L-Cys) and DL-Propargylglycine (DL-PAG) on the changes induced by a high-fat diet (HFD) in zoometric and metabolic variables as well as cardiovascular changes such as hypertension and sympathetic hyperactivity. For this purpose, male Wistar rats were fed a normal fat diet (NFD) or HFD for 12 weeks. Next, the HFD rats were divided into 5 subgroups which received daily i.p. injections during 4 weeks of: (1) nothing (no injection, Control); (2) vehicle (PBS; 1ml/kg); (3) NaHS (5.6 mg/kg); (4) L-Cys (300mg/kg); or (5) DL-PAG (1mg/kg). Then, an oral glucose tolerance test, hormone serum levels and blood pressure were determined. The cardiovascular responses to stimulation of the vasopressor sympathetic tone or intravenous administration of the agonists noradrenaline (α-adrenoceptors), methoxamine (α-adrenoceptors) and UK 14,304 (α-adrenoceptors) were determined in pithed rats. Lastly, the heart, liver and adipose tissue were weighted. HFD significantly increased: (1) zoometric variables, which were decreased by NaHS and L-Cys; (2) metabolic variables, ameliorated by DL-PAG; (3) haemodynamic variables, which were reversed by NaHS and L-Cys; and (4) the vasopressor responses induced by sympathetic stimulation, which were diminished by NaHS and L-Cys. In conclusion, chronic treatment with NaHS and L-Cys are effective in reducing adipose tissue and ameliorating the cardiovascular changes induced by obesity; meanwhile, DL-PAG ameliorates metabolic variables.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejphar.2019.172707DOI Listing

Publication Analysis

Top Keywords

nahs l-cys
16
cardiovascular changes
12
changes induced
12
metabolic variables
12
nahs l-cysteine
8
induced high-fat
8
high-fat diet
8
chronic treatment
8
adipose tissue
8
nahs
7

Similar Publications

Sulfur mustard (SM), a blister agent and toxic chemical warfare compound, leads to injuries in the skin, eyes, and lungs, with early diagnosis being difficult because of its incubation period. Developing scavengers for sulfur mustard (SM) and its simulant, 2-chloroethylsulfide (CEES), is essential due to the severe and long-lasting toxic effects these compounds have on the human body. Existing scavengers like cysteine, sodium hydrosulfide (NaHS), and sodium thiosulfate cannot cross the blood-brain barrier (BBB), rendering them ineffective for detoxifying SM in the brain and highlighting the need for lipophilic scavengers.

View Article and Find Full Text PDF

Neuroprotective Actions of Hydrogen Sulfide-Releasing Compounds in Isolated Bovine Retinae.

Pharmaceuticals (Basel)

October 2024

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004, USA.

We have evidence that hydrogen sulfide (HS)-releasing compounds can reduce intraocular pressure in normotensive and glaucomatous rabbits by increasing the aqueous humor (AH) outflow through the trabecular meshwork. Since HS has been reported to possess neuroprotective actions, the prevention of retinal ganglion cell loss is an important strategy in the pharmacotherapy of glaucoma. Consequently, the present study aimed to investigate the neuroprotective actions of HS-releasing compounds against hydrogen peroxide (HO)-induced oxidative stress in an isolated bovine retina.

View Article and Find Full Text PDF

The Effects of Different Thiol-Containing Compounds on the Degradation of Sulforaphene.

Molecules

September 2024

Shandong Provincial Key Laboratory of Test Technology on Food Quality and Safety, Institute of Quality Standard and Testing Technology for Agro-Products, Shandong Academy of Agricultural Sciences, Jinan 250100, China.

Sulforaphene (4-methylsufinyl-3-butenyl isothiocyanate, SFE), produced by myrosinase hydrolysis of glucoraphenin (4-methylsulfinyl-3-butenyl glucosinolate) found in radish seeds, is strongly associated with cancer prevention. In this study, we investigated the stability of SFE (purity above 98%) under various thiol-containing compounds at 25 °C, such as sodium hydrosulfide (NaHS), glutathione (GSH), and cysteine (Cys). We observed that the degradation of SFE was closely related to the presence and dissociation capacity of thiol-containing compounds in the solution, particularly the thiol group.

View Article and Find Full Text PDF

Hydrogen sulfide alleviates cadmium stress in germinating carrot seeds by promoting the accumulation of proline.

J Plant Physiol

December 2024

State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, College of Horticulture, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China. Electronic address:

Article Synopsis
  • Carrots, an economically important vegetable, can suffer from cadmium pollution in the soil, which harms their growth and poses health risks to humans.
  • To combat this, researchers treated germinating carrot seeds with sodium hydrosulfide (NaHS), discovering that a 0.25 mM concentration improved germination compared to lower and higher amounts.
  • The study also found that NaHS treatment increased the activity of specific enzymes, boosted proline levels, enhanced antioxidant defenses, and reduced cadmium uptake, ultimately improving seed vitality and growth despite Cd stress.
View Article and Find Full Text PDF
Article Synopsis
  • * Findings show that As(V) toxicity negatively impacts root and shoot growth, increases reactive oxygen species, disrupts enzyme activity in detoxifying processes, and elevates lipid and protein oxidation.
  • * Treatment with NO and HS mitigates As(V) damage, but using inhibitors increased toxicity, suggesting that while NO and HS work effectively to combat As(V), they do so independently rather than through a combined signaling system.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: